Sodium Hyaluronate structure
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Common Name | Sodium Hyaluronate | ||
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CAS Number | 9067-32-7 | Molecular Weight | 799.63800 | |
Density | 1.78g/cm3 | Boiling Point | 791.6ºC | |
Molecular Formula | C14H22NNaO11 | Melting Point | N/A | |
MSDS | USA | Flash Point | 432.5ºC |
Use of Sodium HyaluronateHyaluronic acid sodium salt is a biopolymer composed of repeating units of disaccharides with various applications. |
Name | Sodium hyaluronate |
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Synonym | More Synonyms |
Description | Hyaluronic acid sodium salt is a biopolymer composed of repeating units of disaccharides with various applications. |
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Related Catalog | |
In Vitro | Hyaluronic acid (HA) is widely used in aesthetic medicine due to its binding ability with a large number of water molecules. It improves tissue hydration and their resistance to mechanical damage. HA plays an important role in wound healing, ovulation, fertilization, signal transduction, and tumor physiology. HA is used in joint diseases such as osteoarthritis or rheumatoid arthritis. HA of a high molecular mass reduces the chemotaxis and migration of inflammatory cells which acts as a good barrier to the inflammatory process and protects against the effects of free radicals. HA is used in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicate its role in tumor markers, liver diseases, and in pharmaceuticals[1]. Hyaluronan plays an important role in cancer growth and metastasis. HA and HA fragment-tumor cell interaction could activate the downstream signaling pathways, promoting cell proliferation, adhesion, migration and invasion, and inducing angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like property, and chemoradioresistance in digestive cancers[2]. |
In Vivo | The impact of applied intra-articular HA has been proven in many studies in animals. Studies on HA have shown that it promotes the synthesis of cartilage matrix, prevents its degradation, reduces inflammation, stimulates the synthesis of endogenous HA, and improves the resilience and moisture of cartilage[1]. High molecular size HA preparations, applied topically, promote healing of fresh skin wounds. They also promote the healing of venous leg ulcers and are useful in the management of chronic wounds[3]. |
References |
[2]. Wu RL, et al. Hyaluronic acid in digestive cancers. J Cancer Res Clin Oncol. 2017 Jan;143(1):1-16. |
Density | 1.78g/cm3 |
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Boiling Point | 791.6ºC |
Molecular Formula | C14H22NNaO11 |
Molecular Weight | 799.63800 |
Flash Point | 432.5ºC |
Exact Mass | 799.22300 |
PSA | 399.71000 |
Storage condition | −20°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Water Solubility | SOLUBLE |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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Hazard Codes | Xi: Irritant; |
Risk Phrases | 36/37/38 |
Safety Phrases | 22-24/25-36/37/39-27-26 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | MT7250000 |
HS Code | 3913900000 |
~% Sodium Hyaluronate CAS#:9067-32-7 |
Literature: WO2005/16341 A1, ; Page/Page column 3 ; |
Precursor 1 | |
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DownStream 1 | |
HS Code | 3913900000 |
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The effects of biological lubricating molecules on flexor tendon reconstruction in a canine allograft model in vivo.
Plast. Reconstr. Surg. 133(5) , 628e-637e, (2014) Using allograft is an attractive alternative for flexor tendon reconstruction because of the lack of donor-site morbidity, and better matching to the intrasynovial environment. The purpose of this stu... |
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CD44 Isoform Status Predicts Response to Treatment with Anti-CD44 Antibody in Cancer Patients.
Clin. Cancer Res. 21 , 2753-62, (2015) CD44, a cell surface glycoprotein, plays important roles in the development, progression, and metastasis of various tumor types. The aim of this study was to investigate how the expression of CD44 iso... |
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Transcription of the Streptococcus pyogenes hyaluronic acid capsule biosynthesis operon is regulated by previously unknown upstream elements.
Infect. Immun. 82(12) , 5293-307, (2014) The important human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]) produces a hyaluronic acid (HA) capsule that plays critical roles in immune evasion. Previous studies showed that the ... |
MFCD00875848 |
β-D-Glucopyranuronic acid, 4-O-[2-(acetylamino)-2,3-dideoxy-β-D-ribo-hexopyranosyl]-, sodium salt (1:1) |
Sodium 4-O-(2-acetamido-2,3-dideoxy-β-D-ribo-hexopyranosyl)-β-D-glucopyranuronate |
hyaluronic acid sodium salt |
EINECS 232-678-0 |