BIBF 1202
Modify Date: 2024-01-06 08:22:35
BIBF 1202 structure
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Common Name | BIBF 1202 | ||
|---|---|---|---|---|
| CAS Number | 894783-71-2 | Molecular Weight | 525.59800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H31N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BIBF 1202BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM. |
| Name | 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, (3Z) |
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| Synonym | More Synonyms |
| Description | BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM. |
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| Related Catalog | |
| Target |
IC50: 62 nM (VEGFR2)[1] |
| In Vitro | The major metabolic pathway for BIBF 1120 is methyl ester cleavage to BIBF 1202. Subsequently, the free carboxyl group of BIBF 1202 is glucuronidated to 1-O-acylglucuronide[2]. |
| References |
| Molecular Formula | C30H31N5O4 |
|---|---|
| Molecular Weight | 525.59800 |
| Exact Mass | 525.23800 |
| PSA | 105.22000 |
| LogP | 3.61430 |
| Storage condition | 2-8℃ |
| 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, (3Z)- |
| BIBF 1202 |