1-(3,4-DICHLOROBENZYL)PIPERAZINE

Modify Date: 2024-01-02 20:51:14

1-(3,4-DICHLOROBENZYL)PIPERAZINE Structure
1-(3,4-DICHLOROBENZYL)PIPERAZINE structure
 Common Name 1-(3,4-DICHLOROBENZYL)PIPERAZINE
CAS Number 86215-36-3 Molecular Weight 264.58
Density N/A Boiling Point 324.4ºC at 760 mmHg
Molecular Formula C11H12Cl3N Melting Point N/A
MSDS Chinese USA Flash Point 150ºC
Symbol GHS06
GHS06		 Signal Word Danger

 Use of 1-(3,4-DICHLOROBENZYL)PIPERAZINE


DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].

 Names

Name 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane,hydrochloride
Synonym More Synonyms

 1-(3,4-DICHLOROBENZYL)PIPERAZINE Biological Activity

Description DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].
Related Catalog
Target

14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT[2]
References

[1]. Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34.  

[2]. Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41.  

[3]. Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61.  

 Chemical & Physical Properties

Boiling Point 324.4ºC at 760 mmHg
Molecular Formula C11H12Cl3N
Molecular Weight 264.58
Flash Point 150ºC
Exact Mass 263.00400
PSA 12.03000
LogP 3.98510

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H319
Precautionary Statements P301 + P310-P305 + P351 + P338
RIDADR UN 2811 6.1 / PGIII
HS Code 2933990090

 Synthetic Route

1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione structure

1-(3,4-dichloro...

CAS#:66504-44-7

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1-(3,4-DICHLOROBENZYL)PIPERAZINE Structure

1-(3,4-DICHLORO...

CAS#:86215-36-3
Literature: Hagen, Eric J.; Halloran, Kevin Patent: US2007/43100 A1, 2007 ; Location in patent: Page/Page column 10-11 ;
1-(3,4-dichlorophenyl)-1,2-cyclopropane-dicarboxylic acid dimethyl ester structure

1-(3,4-dichloro...

CAS#:877397-17-6

~%

1-(3,4-DICHLOROBENZYL)PIPERAZINE Structure

1-(3,4-DICHLORO...

CAS#:86215-36-3
Literature: EUTHYMIC BIOSCIENCE, INC.; MCKINNEY, Anthony, Alexander; BYMASTER, Frank; PISKORSKI, Walter Patent: WO2012/75473 A1, 2012 ;
3,4-Dichlorophenylacetonitrile structure

3,4-Dichlorophe...

CAS#:3218-49-3

~%

1-(3,4-DICHLOROBENZYL)PIPERAZINE Structure

1-(3,4-DICHLORO...

CAS#:86215-36-3
Literature: EUTHYMIC BIOSCIENCE, INC.; MCKINNEY, Anthony, Alexander; BYMASTER, Frank; PISKORSKI, Walter Patent: WO2012/75473 A1, 2012 ;
α-bromo-3,4-dichlorophenylacetic acid methyl ester structure

α-bromo-3,4-dic...

CAS#:163339-71-7

~%

1-(3,4-DICHLOROBENZYL)PIPERAZINE Structure

1-(3,4-DICHLORO...

CAS#:86215-36-3
Literature: EUTHYMIC BIOSCIENCE, INC.; MCKINNEY, Anthony, Alexander; BYMASTER, Frank; PISKORSKI, Walter Patent: WO2012/75473 A1, 2012 ;
1-(3,4-dichloro-phenyl)cyclopropane-1,2-dicarboxylic acid structure

1-(3,4-dichloro...

CAS#:344245-65-4

~%

1-(3,4-DICHLOROBENZYL)PIPERAZINE Structure

1-(3,4-DICHLORO...

CAS#:86215-36-3
Literature: EUTHYMIC BIOSCIENCE, INC.; MCKINNEY, Anthony, Alexander; BYMASTER, Frank; PISKORSKI, Walter Patent: WO2012/75473 A1, 2012 ;
Methyl (3,4-dichlorophenyl)acetate structure

Methyl (3,4-dic...

CAS#:6725-44-6

~%

1-(3,4-DICHLOROBENZYL)PIPERAZINE Structure

1-(3,4-DICHLORO...

CAS#:86215-36-3
Literature: EUTHYMIC BIOSCIENCE, INC.; MCKINNEY, Anthony, Alexander; BYMASTER, Frank; PISKORSKI, Walter Patent: WO2012/75473 A1, 2012 ;

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

dov 216,303 hydrochloride
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