Boc-NH-PEG4-CH2CH2NH2

Modify Date: 2024-01-11 11:09:50

Boc-NH-PEG4-CH2CH2NH2 structure	Common Name	Boc-NH-PEG4-CH2CH2NH2
	CAS Number	811442-84-9	Molecular Weight	336.42400
	Density	1.059	Boiling Point	N/A
	Molecular Formula	C₁₅H₃₂N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	222 °C

Use of Boc-NH-PEG4-CH2CH2NH2

Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	tert-Butyl (14-amino-3,6,9,12-tetraoxatetradecyl)carbamate
Synonym	More Synonyms

Description	Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Hans-Georg Lerchen, et al. Preparation of antibody drug conjugates of kinesin spindle protein (KSP) inhibitors with anti-TWEAKR-antibodies. WO2016207094A1.

Density	1.059
Molecular Formula	C₁₅H₃₂N₂O₆
Molecular Weight	336.42400
Flash Point	222 °C
Exact Mass	336.22600
PSA	101.27000
LogP	1.62740

Hazard Codes	Xi
HS Code	2924199090

Di-tert-butyl d...

CAS#:24424-99-5

Amino-PEG4-C2-amine

CAS#:68960-97-4

~64%

Boc-NH-PEG4-CH2...

CAS#:811442-84-9

Literature: Ishida, Manabu; Watanabe, Hideaki; Takigawa, Kazumasa; Kurishita, Yasutaka; Oki, Choji; Nakamura, Akinobu; Hamachi, Itaru; Tsukiji, Shinya Journal of the American Chemical Society, 2013 , vol. 135, # 34 p. 12684 - 12689

Precursor 2
CAS#:24424-99-5 Di-tert-butyl d... CAS#:68960-97-4 Amino-PEG4-C2-amine
DownStream 0

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%