1,1-Bis(p-chlorophenyl)methyl-carbinol

Modify Date: 2024-01-04 17:51:53

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure
1,1-Bis(p-chlorophenyl)methyl-carbinol structure
 Common Name 1,1-Bis(p-chlorophenyl)methyl-carbinol
CAS Number 80-06-8 Molecular Weight 267.15000
Density N/A Boiling Point N/A
Molecular Formula C14H12Cl2O Melting Point 69-71°C
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS09
GHS07, GHS09		 Signal Word Warning

 Use of 1,1-Bis(p-chlorophenyl)methyl-carbinol


Chlorfenethol is a dehydrochlorinase inhibitor. Chlorfenethol can be used as a synergist for insecticide DDT to increase its effect on resistant strains[1].

 Names

Name chlorfenethol
Synonym More Synonyms

 1,1-Bis(p-chlorophenyl)methyl-carbinol Biological Activity

Description Chlorfenethol is a dehydrochlorinase inhibitor. Chlorfenethol can be used as a synergist for insecticide DDT to increase its effect on resistant strains[1].
Related Catalog
Target

dehydrochlorinase[1]
References

[1]. Maestre-Serrano R, et al. Susceptibility to insecticides and resistance mechanisms in Aedes aegypti from the Colombian Caribbean Region. Pestic Biochem Physiol. 2014 Nov;116:63-73.  

[2]. W. R. Halliday, et al. Inheritance of Resistance to Permethrin and DDT in the Southern House Mosquito (Diptera: Culicidae), Journal of Economic Entomology, Volume 78, Issue 4, 1 August 1985, Pages 762–767,

 Chemical & Physical Properties

Melting Point 69-71°C
Molecular Formula C14H12Cl2O
Molecular Weight 267.15000
Exact Mass 266.02700
PSA 20.23000
LogP 4.24920

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DC7875000
CHEMICAL NAME :
Benzhydrol, 4,4'-dichloro-alpha-methyl-
CAS REGISTRY NUMBER :
80-06-8
BEILSTEIN REFERENCE NO. :
2505345
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C14-H12-Cl2-O
MOLECULAR WEIGHT :
267.16
WISWESSER LINE NOTATION :
GR DXQ1&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705) Volume(issue)/page/year: 20,8,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,15,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
725 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,148,1968
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 72,304,1949

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H411
Precautionary Statements P273
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;N: Dangerous for the environment;
Risk Phrases R22
Safety Phrases S22-S36/37/39-S61-S36
RIDADR 2811
RTECS DC7875000

 Synthetic Route

METHYLMAGNESIUM BROMIDE structure

METHYLMAGNESIUM...

CAS#:75-16-1
4,4'-Dichlorobenzophenone structure

4,4'-Dichlorobe...

CAS#:90-98-2

~%

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure

1,1-Bis(p-chlor...

CAS#:80-06-8
Literature: Kao, Hsien-Ming; Grey, Clare P.; Pitchumani, Kasi; Lakshminarasimhan; Ramamurthy Journal of Physical Chemistry A, 1998 , vol. 102, # 28 p. 5627 - 5638
ethyl acetate structure

ethyl acetate

CAS#:141-78-6

~%

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure

1,1-Bis(p-chlor...

CAS#:80-06-8
Literature: Uddin, Md. Khabir; Fujio, Mizue; Kim, Hyun-Joong; Rappoport, Zvi; Tsuno, Yuho Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 6 p. 1371 - 1379
ethyl acetate structure

ethyl acetate

CAS#:141-78-6
Bromo(4-chlorophenyl)magnesium structure

Bromo(4-chlorop...

CAS#:873-77-8

~%

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure

1,1-Bis(p-chlor...

CAS#:80-06-8
Literature: Grummitt Science (Washington, DC, United States), 1950 , vol. 111, p. 361
Benzene,1,1'-ethenylidenebis[4-chloro- structure

Benzene,1,1'-et...

CAS#:2642-81-1

~%

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure

1,1-Bis(p-chlor...

CAS#:80-06-8
Literature: Kao, Hsien-Ming; Grey, Clare P.; Pitchumani, Kasi; Lakshminarasimhan; Ramamurthy Journal of Physical Chemistry A, 1998 , vol. 102, # 28 p. 5627 - 5638
METHYLMAGNESIUM IODIDE structure

METHYLMAGNESIUM...

CAS#:917-64-6
4,4'-Dichlorobenzophenone structure

4,4'-Dichlorobe...

CAS#:90-98-2

~%

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure

1,1-Bis(p-chlor...

CAS#:80-06-8
Literature: Bergmann; Bondi Chemische Berichte, 1931 , vol. 64, p. 1455,1480 Chemische Berichte, 1933 , vol. 66, p. 286,291 Full Text Show Details Forrest; Stephenson; Waters Journal of the Chemical Society, 1946 , p. 333,339
p,p'-DDE structure

p,p'-DDE

CAS#:72-55-9

~%

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure

1,1-Bis(p-chlor...

CAS#:80-06-8
Literature: Forrest; Stephenson; Waters Journal of the Chemical Society, 1946 , p. 333,339
Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7
Bromo(4-chlorophenyl)magnesium structure

Bromo(4-chlorop...

CAS#:873-77-8

~%

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure

1,1-Bis(p-chlor...

CAS#:80-06-8
Literature: Monsanto Chem. Co. Patent: US2704300 , 1953 ;
4-Bromochlorobenzene structure

4-Bromochlorobenzene

CAS#:106-39-8
ethyl acetate structure

ethyl acetate

CAS#:141-78-6

~86%

1,1-Bis(p-chlorophenyl)methyl-carbinol Structure

1,1-Bis(p-chlor...

CAS#:80-06-8
Literature: Gao, Fei; Deng, Xiang-Jun; Tang, Yu; Tang, Jin-Peng; Yang, Jun; Zhang, Yuan-Ming Tetrahedron Letters, 2014 , vol. 55, # 4 p. 880 - 883

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 Synonyms

4-chloro-α-(4-chlorophenyl)-α-methylbenzenemethanol
1,1-bis(4-chlorophenyl)ethan-1-ol
MFCD00000628
4,4'-Dichloro-alpha-methylbenzhydrol
EINECS 201-246-3
4,4’-dichloro-α-methylbenzhydryl alcohol
1,1-bis(4-chlorophenyl)ethanol
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