Neridronate

Modify Date: 2024-01-07 05:30:59

Neridronate Structure
Neridronate structure
Common Name Neridronate
CAS Number 79778-41-9 Molecular Weight 277.149
Density 1.7±0.1 g/cm3 Boiling Point 600.1±65.0 °C at 760 mmHg
Molecular Formula C6H17NO7P2 Melting Point 245°
MSDS Chinese USA Flash Point 316.7±34.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Neridronate


Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget’s disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases[1][2].

 Names

Name neridronate sodium hydrate
Synonym More Synonyms

 Neridronate Biological Activity

Description Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget’s disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases[1][2].
Related Catalog
References

[1]. Gatti D, et al. Clinical development of neridronate: potential for new applications. Ther Clin Risk Manag. 2013;9:139-47.

[2]. Guiducci L, et al. Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study. Int J Endocrinol. 2019 Feb 6;2019:9802827.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 600.1±65.0 °C at 760 mmHg
Melting Point 245°
Molecular Formula C6H17NO7P2
Molecular Weight 277.149
Flash Point 316.7±34.3 °C
Exact Mass 277.048035
PSA 180.93000
LogP -3.36
Vapour Pressure 0.0±3.9 mmHg at 25°C
Index of Refraction 1.569
Storage condition 2-8°C
Water Solubility H2O: 8 mg/mL, soluble

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles26

More Articles
Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment.

Eur. J. Pharm. Biopharm. 76(1) , 120-6, (2010)

Recognition of bone mineral by bisphosphonates is crucial to their targeting, efficacy, therapeutic and diagnostic applications, and pharmacokinetics. In a search for rapid and simple NMR approaches t...

Intramuscular neridronate in postmenopausal women with low bone mineral density.

Calcif. Tissue Int. 83(5) , 301-7, (2008)

Compliance to osteoporosis treatment with oral bisphosphonates is very poor. Intermittent intravenous bisphosphonate is a useful alternative, but this route is not readily available. Neridronate, a ni...

The use of intravenous aminobisphosphonates for the treatment of Paget's disease of bone.

Mini Rev. Med. Chem. 9(9) , 1052-63, (2009)

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, a widely used immunosuppressant. Numerous studies have developed limited sampling strategies (LSSs) to predict MPA AUC in sol...

 Synonyms

(6-Amino-1-hydroxy-1,1-hexanediyl)bis(phosphonic acid)
Neridronic
6-amino-1-hydroxyhexane-1,1-diphosphonic acid
NERIXIA
6-amino-1-hydroxy-1,1-hexylidenebisphosphonic acid
Phosphonic acid, (6-amino-1-hydroxyhexylidene)bis-
(6-amino-1-hydroxyhexylidene)bisphosphonate
6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID
6-Amino-1-hydroxyhexylidene bisphosphonic acid,Neridronic acid,Nerixia
6-amino-1-hydroxyhexane-1,1-diphosphonate
(6-amino-1-hydroxy-1-phosphonohexyl)phosphonic acid
(6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid)
NERIDRONATE
Neridronic acid
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