4-Hydroxy-3-methoxystyrene

Modify Date: 2024-01-02 23:30:57

4-Hydroxy-3-methoxystyrene Structure
4-Hydroxy-3-methoxystyrene structure
Common Name 4-Hydroxy-3-methoxystyrene
CAS Number 7786-61-0 Molecular Weight 150.174
Density 1.1±0.1 g/cm3 Boiling Point 245.0±20.0 °C at 760 mmHg
Molecular Formula C9H10O2 Melting Point 25-29°C
MSDS Chinese USA Flash Point 111.3±6.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 4-Hydroxy-3-methoxystyrene


2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects[1][2].

 Names

Name 2-methoxy-4-vinylphenol
Synonym More Synonyms

 4-Hydroxy-3-methoxystyrene Biological Activity

Description 2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects[1][2].
Related Catalog
In Vitro 2-Methoxy-4-vinylphenol (2M4VP) potently inhibits the translocation of NF-κB p65 into the nucleus by IκB degradation following IκB-α phosphorylation and the phosphorylation of MAPKs such as p38, ERK1/2, and JNK[1]. 2-Methoxy-4-vinylphenol (2M4VP) inhibits hyper-acetylation of histone H3 (Lys9/Lys14) induced by LPS[1]. Western Blot Analysis[1] Cell Line: RAW264.7 cells. Concentration: 0-40 μM. Incubation Time: 24 h. Result: Inhibited the over-expression of iNOS and COX-2 protein in LPS-stimulated RAW264.7 cells.
References

[1]. Jin Boo Jeong, et al. Anti-inflammatory Effect of 2-methoxy-4-vinylphenol via the Suppression of NF-κB and MAPK Activation, and Acetylation of Histone H3. Arch Pharm Res. 2011 Dec;34(12):2109-16.

[2]. Hossein Reza Darabi, et al. A Structure-Activity Relationship Study on a Natural Germination Inhibitor, 2-methoxy-4-vinylphenol (MVP), in Wheat Seeds to Evaluate Its Mode of Action. Z Naturforsch C J Biosci. Sep-Oct 2007;62(9-10):694-700.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 245.0±20.0 °C at 760 mmHg
Melting Point 25-29°C
Molecular Formula C9H10O2
Molecular Weight 150.174
Flash Point 111.3±6.7 °C
Exact Mass 150.068085
PSA 29.46000
LogP 1.93
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.578
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL8205000
CHEMICAL NAME :
Phenol, 2-methoxy-4-vinyl-
CAS REGISTRY NUMBER :
7786-61-0
BEILSTEIN REFERENCE NO. :
2044521
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H10-O2
MOLECULAR WEIGHT :
150.19
WISWESSER LINE NOTATION :
1U1R DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1400 mg/kg
SEX/DURATION :
female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS SL8205000
HS Code 2909500000

 Synthetic Route

 Customs

HS Code 2909500000
Summary 2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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 Synonyms

p-Vinyl guaiacol
p-vinylguaiacol
MFCD00015437
3-06-00-04981 (Beilstein Handbook Reference)
o-Methoxy-p-vinylphenol
2-Methoxy-4-vinylphenol
Phenol, 2-methoxy-4-vinyl-
Phenol, 4-ethenyl-2-methoxy-
4-Hydroxy-3-methoxystyrene
2-Methoxy-4-ethenylphenol
EINECS 232-101-2
2-METHOXY-4-VINYL-PHENOL
3-Methoxy-4-hydroxystyrene
4-ETHENYL-2-METHOXYPHENOL
4-VINYLGUAIACOL
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