CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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NJ5907000
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CHEMICAL NAME :
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3H-Imidazo(4,5-f)quinoline, 2-amino-3,4-dimethyl-
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CAS REGISTRY NUMBER :
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77094-11-2
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LAST UPDATED :
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199807
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DATA ITEMS CITED :
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30
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MOLECULAR FORMULA :
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C12-H12-N4
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MOLECULAR WEIGHT :
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212.28
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5040 mg/kg/40W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Endocrine - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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7476 mg/kg/89W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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22120 mg/kg/81W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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27888 mg/kg/83W-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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Morphological transformation
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TYPE OF TEST :
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DNA damage
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TYPE OF TEST :
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DNA damage
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TYPE OF TEST :
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DNA damage
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TYPE OF TEST :
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Sister chromatid exchange
MUTATION DATA
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TYPE OF TEST :
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Unscheduled DNA synthesis
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TEST SYSTEM :
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Rodent - guinea pig Lung
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DOSE/DURATION :
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10 umol/L
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REFERENCE :
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ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,245,1985 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993
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