Etamicastat

Modify Date: 2024-01-14 12:31:17

Etamicastat structure	Common Name	Etamicastat
	CAS Number	760173-05-5	Molecular Weight	311.35
	Density	1.44	Boiling Point	435.308ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₅F₂N₃OS	Melting Point	N/A
	MSDS	N/A	Flash Point	217.067ºC

Use of Etamicastat

Etamicastat (BIA 5-453) is a potent and reversible peripheral dopamine-β-hydroxylase (DβH) inhibitor[1].

Name	4-(2-aminoethyl)-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione
Synonym	More Synonyms

Description	Etamicastat (BIA 5-453) is a potent and reversible peripheral dopamine-β-hydroxylase (DβH) inhibitor[1].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	Dopamine-β-hydroxylase (DβH)[1]
In Vivo	Upon intraperitoneal administration to NMRi mice, Etamicastat (100 mg/ kg) leads to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control)[2]. Etamicastat (50 mg/kg) is rapidly absorbed into the systemic circulation reaching a maximum concentration at 4 h post-administration, representing 29% of total Etamicastat and quantified metabolites, using AUC0-t as a measure of systemic exposure[2].
References	[1]. Vaz-da-Silva M, et al. Effect of food on the pharmacokinetic profile of Etamicastat (BIA 5-453). Drugs R D. 2011;11(2):127-36. [2]. Loureiro AI, et al. Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat. Eur J Pharmacol. 2014 Oct 5;740:285-94.

Density	1.44
Boiling Point	435.308ºC at 760 mmHg
Molecular Formula	C₁₄H₁₅F₂N₃OS
Molecular Weight	311.35
Flash Point	217.067ºC
Exact Mass	311.09000
PSA	91.87000
LogP	2.82770

Precursor 8
CAS#:677773-32-9 Etamicastat hyd... CAS#:1044596-95-3 (R)-2-{2-[3--(6... CAS#:1043421-43-7 6,8-difluoro-2H... CAS#:1151797-94-2 6,8-difluoro-2H...
CAS#:1034001-13-2 methyl N-(6,8-d... CAS#:1044596-89-5 (R)-2-amino-3-(... CAS#:1184842-84-9 (S)-3-(2,4-difl... CAS#:1044597-03-6 (R)-6,8-difluor...
DownStream 0

UNII-9X96V6DBU4

Etamitat

DC Chemicals Limited
China
Product Name: Etamicastat
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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