H-Leu-OMe.HCl

Modify Date: 2024-01-02 17:10:27

H-Leu-OMe.HCl Structure
H-Leu-OMe.HCl structure
 Common Name H-Leu-OMe.HCl
CAS Number 7517-19-3 Molecular Weight 181.660
Density 0.955 g/cm3 Boiling Point 169.2ºC at 760 mmHg
Molecular Formula C7H16ClNO2 Melting Point 151-153 °C(lit.)
MSDS Chinese USA Flash Point N/A

 Use of H-Leu-OMe.HCl


H-Leu-OMe.HCl is a leucine derivative[1].

 Names

Name Methyl L-leucinate hydrochloride
Synonym More Synonyms

 H-Leu-OMe.HCl Biological Activity

Description H-Leu-OMe.HCl is a leucine derivative[1].
Related Catalog
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

 Chemical & Physical Properties

Density 0.955 g/cm3
Boiling Point 169.2ºC at 760 mmHg
Melting Point 151-153 °C(lit.)
Molecular Formula C7H16ClNO2
Molecular Weight 181.660
Exact Mass 181.086960
PSA 52.32000
LogP 2.03510
Index of Refraction 13 ° (C=2, H2O)
Storage condition 0-6°C
Water Solubility soluble

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29224995

 Synthetic Route

Methanol structure

Methanol

CAS#:67-56-1
L-leucine structure

L-leucine

CAS#:61-90-5

~96%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: McKerrow, Jason D.; Al-Rawi, Jasim M. A.; Brooks, Peter Synthetic Communications, 2010 , vol. 40, # 8 p. 1161 - 1179
L-leucine structure

L-leucine

CAS#:61-90-5

~10%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: Takeda Chemical Industries, Ltd. Patent: US6420415 B1, 2002 ;
(2S)-methyl 2-(2-azabicyclo[2.2.1]hept-5-en-2-yl)-4-methylpentanoate structure

(2S)-methyl 2-(...

CAS#:112018-28-7

~97%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: Grieco, Paul A.; Clark, Jerry D. Journal of Organic Chemistry, 1990 , vol. 55, # 8 p. 2271 - 2272
N/A structure

N/A

CAS#:128369-74-4

~99%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: Mandal, Pijus K.; McMurray, John S. Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6599 - 6601
methyl (S)-2-methoxycarbonylamino-4-methyl-valerate structure

methyl (S)-2-me...

CAS#:113089-14-8

~%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: US5523463 A1, ;
methyl L-leucinate structure

methyl L-leucinate

CAS#:2666-93-5

~%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: Synlett, , # 17 p. 2803 - 2808
Z-Leu-Ome structure

Z-Leu-Ome

CAS#:51021-87-5

~%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: Synthesis, , # 20 art. no. N44611SS, p. 3247 - 3254
L-leucine structure

L-leucine

CAS#:61-90-5
2,2-Dimethoxypropane structure

2,2-Dimethoxypropane

CAS#:77-76-9

~%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: Tetrahedron Asymmetry, , vol. 19, # 1 p. 67 - 81
Methanol structure

Methanol

CAS#:67-56-1
L-leucyl chloride structure

L-leucyl chloride

CAS#:120335-08-2

~%

H-Leu-OMe.HCl Structure

H-Leu-OMe.HCl

CAS#:7517-19-3
Literature: Tetrahedron, , vol. 63, # 41 p. 10282 - 10289

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles28

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Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...
Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor.

Cell Death Dis. 5 , e1409, (2014)

Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancie...
Primary in vitro immunization with multimeric synthetic peptides of HIV-1 envelope glycoproteins: generation of neutralizing human monoclonal antibodies.

J. Immunol. Methods 176(1) , 9-22, (1994)

Peripheral blood lymphocytes from healthy HIV-1 seronegative donors were immunized in vitro with the following synthetic peptides: (i) an octameric poly-L-lysine conjugated peptide of the HIV-1MN V3 l...

 Synonyms

Methyl L-leucinate hydrochloride (1:1)
L-Leucine, methyl ester, hydrochloride (1:1)
EINECS 231-375-0
L-Leucine, methyl ester, hydrochloride
MFCD00012494
methyl (2S)-2-amino-4-methylpentanoate,hydrochloride
H-Leu-OMe·HCl
H-Leu-OMe.HCl
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