tert-Butyl Hydroperoxide

Modify Date: 2024-01-02 13:54:20

tert-Butyl Hydroperoxide Structure
tert-Butyl Hydroperoxide structure
Common Name tert-Butyl Hydroperoxide
CAS Number 75-91-2 Molecular Weight 90.121
Density 0.9±0.1 g/cm3 Boiling Point 120.4±9.0 °C at 760 mmHg
Molecular Formula C4H10O2 Melting Point -2.8 °C
MSDS Chinese USA Flash Point 35.0±0.0 °C
Symbol GHS02 GHS05 GHS06 GHS08 GHS09
GHS02, GHS05, GHS06, GHS08, GHS09
Signal Word Danger

 Names

Name tert-butyl hydroperoxide
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 120.4±9.0 °C at 760 mmHg
Melting Point -2.8 °C
Molecular Formula C4H10O2
Molecular Weight 90.121
Flash Point 35.0±0.0 °C
Exact Mass 90.068077
PSA 29.46000
LogP 1.38
Vapour Pressure 7.4±0.5 mmHg at 25°C
Index of Refraction 1.399
Stability Stable, but may explode if heated under confinement. Decomposition may be accelerated by traces of metals, molecular sieve or other contaminants. Incompatible with reducing agents, combustible material, acids.
Water Solubility Miscible

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EQ4900000
CHEMICAL NAME :
tert-Butylhydroperoxide
CAS REGISTRY NUMBER :
75-91-2
BEILSTEIN REFERENCE NO. :
1098280
LAST UPDATED :
199806
DATA ITEMS CITED :
38
MOLECULAR FORMULA :
C4-H10-O2
MOLECULAR WEIGHT :
90.14
WISWESSER LINE NOTATION :
QOX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Rinsed with water
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Behavioral - irritability Gastrointestinal - alteration in gastric secretion Blood - hemorrhage
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 ppm/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
790 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
87 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Behavioral - irritability Gastrointestinal - alteration in gastric secretion Blood - hemorrhage
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 ppm/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
246 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
460 uL/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
107 mg/m3/17W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - change in sensation of smell Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in chlorine
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
365 mg/kg/7W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
107 mg/m3/17W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Dominant lethal test

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
34 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14730 No. of Facilities: 75 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 433 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14730 No. of Facilities: 266 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 12168 (estimated) No. of Female Employees: 4787 (estimated)

 Safety Information

Symbol GHS02 GHS05 GHS06 GHS08 GHS09
GHS02, GHS05, GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H226-H242-H302-H304-H311 + H331-H314-H317-H336-H341-H410
Precautionary Statements P210-P234-P280-P301 + P310-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P331-P403 + P233
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive
Risk Phrases R10;R20/21/22;R34;R43;R52/53;R7
Safety Phrases S14-S3/7-S61-S45-S36/37/39-S24-S17-S16-S14A-S26-S62
RIDADR UN 3109 5.2
WGK Germany 3
RTECS EQ4900000
Packaging Group II
Hazard Class 5.2

 Synthetic Route

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 Synonyms

2-hydroperoxy-2-methylpropane
MFCD00002130
EINECS 200-915-7
tert-Butyl hydroperoxide
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