LY125180

Modify Date: 2024-03-05 16:39:22

LY125180 Structure
LY125180 structure
Common Name LY125180
CAS Number 74515-39-2 Molecular Weight 305.84
Density N/A Boiling Point N/A
Molecular Formula C18H24ClNO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LY125180


LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively[1].

 Names

Name N,N-dimethyl-3-(4-methylphenoxy)-1-phenylpropan-1-amine,hydrochloride
Synonym More Synonyms

 LY125180 Biological Activity

Description LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively[1].
Related Catalog
References

[1]. Wong DT, et al. N,N-Dimethyl-alpha-[2-(p-tolyloxy)ethyl]benzylamine hydrochloride (LY125180). Effects on serotonin uptake and serotonin synthesis in rat brain in vitro and in vivo. Biochem Pharmacol. 1980 Mar 15;29(6):935-41.  

 Chemical & Physical Properties

Molecular Formula C18H24ClNO
Molecular Weight 305.84
Exact Mass 305.15500
PSA 12.47000
LogP 4.86880

 Synonyms

N,N-dimethyl-3-(4-methylphenoxy)-1-phenylpropan-1-amine hydrochloride
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