1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione

Modify Date: 2024-01-09 19:45:19

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure
1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione structure
Common Name 1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
CAS Number 73971-82-1 Molecular Weight 267.24
Density N/A Boiling Point N/A
Molecular Formula C10H13N5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione


3-epi-Azido-3-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 3'-Azido-2',3'-dideoxy-3,4-dihydrothymidine
Synonym More Synonyms

  Biological Activity

Description 3-epi-Azido-3-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C10H13N5O4
Molecular Weight 267.24
Exact Mass 267.09700
PSA 134.33000

 Synthetic Route

~83%

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure

1-[(2R,4R,5S)-4...

CAS#:73971-82-1

Literature: Dong, Guimin; Zhang, Liangren; Zhang, Lihe Helvetica Chimica Acta, 2003 , vol. 86, # 10 p. 3516 - 3524

~%

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure

1-[(2R,4R,5S)-4...

CAS#:73971-82-1

Literature: Dong, Guimin; Zhang, Liangren; Zhang, Lihe Helvetica Chimica Acta, 2003 , vol. 86, # 10 p. 3516 - 3524

~%

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure

1-[(2R,4R,5S)-4...

CAS#:73971-82-1

Literature: Wengel; Pedersen Synthesis, 1991 , # 6 p. 451 - 454

~%

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure

1-[(2R,4R,5S)-4...

CAS#:73971-82-1

Literature: Gauthier, Christine; Ramondenc, Yvan; Ple, Gerard Tetrahedron, 2001 , vol. 57, # 35 p. 7513 - 7517

~%

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure

1-[(2R,4R,5S)-4...

CAS#:73971-82-1

Literature: Gauthier, Christine; Ramondenc, Yvan; Ple, Gerard Tetrahedron, 2001 , vol. 57, # 35 p. 7513 - 7517

~%

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure

1-[(2R,4R,5S)-4...

CAS#:73971-82-1

Literature: Wengel; Pedersen Synthesis, 1991 , # 6 p. 451 - 454

~%

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure

1-[(2R,4R,5S)-4...

CAS#:73971-82-1

Literature: Sun, Jingbo; Liu, Xinyu; Li, Hongming; Duan, Ronghui; Wu, Jinchang Helvetica Chimica Acta, 2012 , vol. 95, # 5 p. 772 - 779

~%

1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione Structure

1-[(2R,4R,5S)-4...

CAS#:73971-82-1

Literature: Wengel; Pedersen Synthesis, 1991 , # 6 p. 451 - 454

 Synonyms

5'OHCH2alloAZT
3'-azido-3'-deoxythymidine
Top Suppliers:I want be here
Hot Compounds More...
Dichloromethane
CAS#:75-09-2
Polyacrylic acid
CAS#:9003-01-4
sodium carbonate
CAS#:497-19-8
Silicon dioxide
CAS#:7631-86-9
Triethanolamine
CAS#:102-71-6
Demeton
CAS#:126-75-0
Water
CAS#:7732-18-5
4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9
Diclofenac sodium
CAS#:15307-79-6
Budesonide
CAS#:51372-29-3