SKF 86002 structure
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Common Name | SKF 86002 | ||
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CAS Number | 72873-74-6 | Molecular Weight | 297.350 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | 476.1±55.0 °C at 760 mmHg | |
Molecular Formula | C16H12FN3S | Melting Point | 189-190ºC(lit.) | |
MSDS | USA | Flash Point | 241.7±31.5 °C |
Use of SKF 86002SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).IC50 value:Target: p38 MAPK inhibitorin vitro: SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100 microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM) [1]. differentiation of HL-60 cells toward the neutrophil phenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition of formylmethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis blockade by SKF-86002 [2]. SKF-86002 blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP [3]. |
Name | 6-(4-fluorophenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole |
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Synonym | More Synonyms |
Description | SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).IC50 value:Target: p38 MAPK inhibitorin vitro: SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100 microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM) [1]. differentiation of HL-60 cells toward the neutrophil phenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition of formylmethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis blockade by SKF-86002 [2]. SKF-86002 blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP [3]. |
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Related Catalog | |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 476.1±55.0 °C at 760 mmHg |
Melting Point | 189-190ºC(lit.) |
Molecular Formula | C16H12FN3S |
Molecular Weight | 297.350 |
Flash Point | 241.7±31.5 °C |
Exact Mass | 297.073608 |
PSA | 56.01000 |
LogP | 1.90 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.713 |
Storage condition | 2-8℃ |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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Hazard Codes | Xi: Irritant; |
Risk Phrases | 36/37/38 |
Safety Phrases | 26-36 |
RIDADR | NONH for all modes of transport |
HS Code | 2934100090 |
~92% SKF 86002 CAS#:72873-74-6 |
Literature: Lantos, Ivan; Gombatz, Kerry; McGuire, Michael; Pridgen, Lendon; Remich, James; Shilcrat, Susan Journal of Organic Chemistry, 1988 , vol. 53, # 18 p. 4223 - 4227 |
~% SKF 86002 CAS#:72873-74-6 |
Literature: Lantos, I.; Bender, P. E.; Razgaitis, K. A.; Sutton, B. M.; DiMartino, M. J.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 72 - 75 |
~% SKF 86002 CAS#:72873-74-6 |
Literature: Lantos, Ivan; Gombatz, Kerry; McGuire, Michael; Pridgen, Lendon; Remich, James; Shilcrat, Susan Journal of Organic Chemistry, 1988 , vol. 53, # 18 p. 4223 - 4227 |
~% SKF 86002 CAS#:72873-74-6 |
Literature: Lantos, I.; Bender, P. E.; Razgaitis, K. A.; Sutton, B. M.; DiMartino, M. J.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 72 - 75 |
HS Code | 2934100090 |
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Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
The discovery of novel chemotypes of p38 kinase inhibitors.
Curr. Top. Med. Chem 5(10) , 953-65, (2005) In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors l... |
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Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.
PLoS ONE 3(5) , e2130, (2008) The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood.Herein we demonstrate that expanded polyglutamine protein cytot... |
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Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines.
Toxicol. Sci. 68(1) , 82-92, (2002) Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid c... |
5-(4-pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo(2,1-b)-thiazole |
MFCD00869367 |
6-(4-Fluorophenyl)-5-(4-pyridinyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole |
6-(4-Fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole |
Imidazo[2,1-b]thiazole, 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)- |
SKF-86002 |