5-methoxytryptophol

Modify Date: 2024-01-02 12:00:13

5-methoxytryptophol structure	Common Name	5-methoxytryptophol
	CAS Number	712-09-4	Molecular Weight	191.22600
	Density	1.224 g/cm3	Boiling Point	393.9ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₃NO₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	192ºC

Use of 5-methoxytryptophol

5-Methoxytryptophol is a natural indole present in the pineal gland.

Name	2-(5-Methoxy-1H-indol-3-yl)-1-ethanol
Synonym	More Synonyms

Description	5-Methoxytryptophol is a natural indole present in the pineal gland.
Related Catalog	Natural Products >> Others Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. Satué M, et al. A new role for 5-methoxytryptophol on bone cells function in vitro. J Cell Biochem. 2015 Apr;116(4):551-8. [2]. Raynaud F, et al. Plasma concentrations of 5-methoxytryptamine, 5-methoxytryptophol and melatonin after 5-methoxytryptamine administration of golden hamsters: physiological implications. J Neural Transm Gen Sect. 1991;84(1-2):33-43.

Density	1.224 g/cm3
Boiling Point	393.9ºC at 760 mmHg
Molecular Formula	C₁₁H₁₃NO₂
Molecular Weight	191.22600
Flash Point	192ºC
Exact Mass	191.09500
PSA	45.25000
LogP	1.71130
Index of Refraction	1.64
Storage condition	2-8°C

5-methoxytryptophol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL8513000

CHEMICAL NAME :: Indole-3-ethanol, 5-methoxy-

CAS REGISTRY NUMBER :: 712-09-4

BEILSTEIN REFERENCE NO. :: 0145680

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H13-N-O2

MOLECULAR WEIGHT :: 191.25

WISWESSER LINE NOTATION :: T56 BMJ D2Q GO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 9333 ug/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 145,63,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 25200 ug/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 30,305,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 240 mg/kg

SEX/DURATION :: female 1-2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JNTMAH Journal of Neural Transmission. (Springer-Verlag, Postfach 367, A-1011 Vienna, Austria) V.33-77, 1972-89. Volume(issue)/page/year: 96,19,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 750 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 83,599,1968

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NL8513000
HS Code	2933990090

Precursor 10
CAS#:1191-99-7 2,3-DHF CAS#:19501-58-7 4-Anisylhydrazi... CAS#:14771-33-6 ethyl 2-(5-meth... CAS#:335451-45-1 1-(tert-Butyldi...
CAS#:3471-31-6 5-Methoxyindole... CAS#:23304-48-5 5-Methoxy-1H-in... CAS#:3471-32-7 p-anisylhydrazine CAS#:57000-49-4 5-methoxy-1H-in...
CAS#:99988-56-4 methyl 2-(5-met... CAS#:1006-94-6 5-Methoxyindole
DownStream 4
CAS#:608-07-1 5-Methoxy-3-ind... CAS#:185558-16-1 3-(2-bromoethyl... CAS#:73-31-4 Melatonine CAS#:1019-45-0 5-Methoxydimeth...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor.

Biochem. Biophys. Res. Commun. 282(5) , 1229-36, (2001)

Site-directed mutation of serine 110 (Ser(3.35)) and serine 114 (Ser(3.39)) in the human melatonin MT(1) receptor to alanine residues reduced ligand binding affinities of seven known melatonin recepto...

Effects of cycloheximide and aminophylline on 5-methoxytryptophol and melatonin contents in the chick pineal gland.

Gen. Comp. Endocrinol. 120(2) , 212-9, (2000)

The chick pineal gland rhythmically synthesizes two 5-methoxyindoles, melatonin and 5-methoxytryptophol. These rhythms are circadian in nature and have opposite phases. The aim of this study was to de...

5-methoxytryptophol preserves hepatic microsomal membrane fluidity during oxidative stress.

J. Cell. Biochem. 76(4) , 651-7, (2000)

Lipid peroxidation is a degenerative chain reaction in biological membranes that may be initiated by exposure to free radicals. This process is associated with changes in the membrane fluidity and los...

EINECS 211-919-3

MFCD00047196

2-(5-methoxy-1H-indol-3-yl)ethanol

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Methoxyindole-3-ethanol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥1500/50 mg

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5-methoxytryptophol

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