DL-threo-2-methylisocitrate

Modify Date: 2024-01-10 19:00:55

DL-threo-2-methylisocitrate Structure
DL-threo-2-methylisocitrate structure
Common Name DL-threo-2-methylisocitrate
CAS Number 71183-66-9 Molecular Weight 412.30
Density N/A Boiling Point N/A
Molecular Formula C14H20O14 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DL-threo-2-methylisocitrate


DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).IC50 value:Target: The Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 μM using Michaelis-Menten non-linear least squares fit, with a kcat of 5.24 s-1. The Km for DL-threo-2-methylisocitrate (MICA) was approximately fourfold higher at 718 μM with a kcat of 1.25 s-1.

 Names

Name DL-threo-2-methylisocitrate

 DL-threo-2-methylisocitrate Biological Activity

Description DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).IC50 value:Target: The Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 μM using Michaelis-Menten non-linear least squares fit, with a kcat of 5.24 s-1. The Km for DL-threo-2-methylisocitrate (MICA) was approximately fourfold higher at 718 μM with a kcat of 1.25 s-1.
Related Catalog
References

[1]. Gould TA, et al. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7.

 Chemical & Physical Properties

Molecular Formula C14H20O14
Molecular Weight 412.30
Storage condition 2-8℃