Bay K-8644
Bay K-8644 structure
|
Common Name | Bay K-8644 | ||
|---|---|---|---|---|
| CAS Number | 71145-03-4 | Molecular Weight | 356.29700 | |
| Density | 1.37g/cm3 | Boiling Point | 404.3ºC at 760 mmHg | |
| Molecular Formula | C16H15F3N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 198.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Bay K-8644Bay K 8644, a dihydropyridine compound, is a specific L-type Ca2+ channel agonist. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel[1]. |
| Name | 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylic acid methyl ester |
|---|---|
| Synonym | More Synonyms |
| Description | Bay K 8644, a dihydropyridine compound, is a specific L-type Ca2+ channel agonist. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel[1]. |
|---|---|
| Related Catalog | |
| In Vitro | In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development[2]. |
| In Vivo | A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats[1]. |
| References |
| Density | 1.37g/cm3 |
|---|---|
| Boiling Point | 404.3ºC at 760 mmHg |
| Molecular Formula | C16H15F3N2O4 |
| Molecular Weight | 356.29700 |
| Flash Point | 198.3ºC |
| Exact Mass | 356.09800 |
| PSA | 84.15000 |
| LogP | 4.19940 |
| Index of Refraction | 1.545 |
| Storage condition | -20℃ |
|
~37%
Bay K-8644 CAS#:71145-03-4 |
| Literature: Bayer Aktiengesellschaft Patent: US4532248 A1, 1985 ; |
|
~33%
Bay K-8644 CAS#:71145-03-4 |
| Literature: Gorlitzer; Schmidt Archiv der Pharmazie, 1991 , vol. 324, # 10 p. 785 - 796 |
|
~21%
Detail
|
| Literature: Gorlitzer; Schmidt Archiv der Pharmazie, 1991 , vol. 324, # 10 p. 785 - 796 |
![1,4-Dihydro-2,6-dimethyl-3,5-dinitro-4-[2-(trifluormethyl)phenyl]-pyridin structure](https://www.chemsrc.com/caspic/378/137481-69-7.png)
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| (1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-pyridine carboxylic acid methyl ester |
| rac-Aziridin-2-carbonitril |
| methyl-1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)-pyridine-3-carboxylate |
| (+/-)-Aziridin-2-carbonitril |
| cyano-2 aziridine |
| (-)-2,6-dimethyl-3-carbomethoxy-5-nitro-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine |
| 2-aziridinecarbonitrile |
| MFCD00036697 |
| 2-cyano-2-aziridine |
| (.+/-.)-Bay K 8644 |
| nitrile of aziridine-2-carboxylic acid |
| Bay K-8644 |