(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE structure
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Common Name | (+)-TUBOCURARINE CHLORIDE PENTAHYDRATE | ||
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CAS Number | 6989-98-6 | Molecular Weight | 771.72200 | |
Density | 1.2074 (rough estimate) | Boiling Point | N/A | |
Molecular Formula | C37H52Cl2N2O11 | Melting Point | 275-280ºC (dec.)(lit.) | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of (+)-TUBOCURARINE CHLORIDE PENTAHYDRATED-Tubocurarine chloride pentahydrate is the chloride salt form of Tubocurarine, a nicotinic acetylcholine receptors (AChR) antagonist, and can be used as a skeletal muscle relaxant during surgery or mechanical ventilation. D-Tubocurarine chloride pentahydrate is also a potent neuromuscular blocking agent[1][2][3]. |
Name | Tubocurarine Chloride Pentahydrate |
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Synonym | More Synonyms |
Description | D-Tubocurarine chloride pentahydrate is the chloride salt form of Tubocurarine, a nicotinic acetylcholine receptors (AChR) antagonist, and can be used as a skeletal muscle relaxant during surgery or mechanical ventilation. D-Tubocurarine chloride pentahydrate is also a potent neuromuscular blocking agent[1][2][3]. |
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Related Catalog | |
In Vitro | Treatment of Caco-2 cells with the AChR antagonist Tubocurarine (10 µM) induces a disorganization of adherents junctions. Buffalo milk-derived products (MBCP) (18 µM) attenuates Tubocurarine AChR antagonist effects on Caco-2 cells adherens junctions[1]. |
References |
Density | 1.2074 (rough estimate) |
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Melting Point | 275-280ºC (dec.)(lit.) |
Molecular Formula | C37H52Cl2N2O11 |
Molecular Weight | 771.72200 |
Exact Mass | 770.29500 |
PSA | 126.77000 |
LogP | 4.08220 |
Index of Refraction | 193 ° (C=1, H2O) |
Storage condition | 2-8°C |
Water Solubility | H2O: soluble50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow | Soluble in water to 50mg/ml, with warming as needed. Also soluble in ethanol or methanol |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T |
Risk Phrases | R25 |
Safety Phrases | S22;S45;S36/S37/S39 |
RIDADR | UN 1544 6.1/PG 3 |
WGK Germany | 3 |
RTECS | YO5100000 |
Packaging Group | III |
Acetylcholine induces Ca2+ signaling in chicken retinal pigmented epithelial cells during dedifferentiation.
Am. J. Physiol. Cell Physiol. 296 , C1195-206, (2009) Retinal pigmented epithelial cells exchange their cellular phenotypes into lens cells and neurons, via depigmented and non-epithelial-shaped dedifferentiated intermediates. Because these dedifferentia... |
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Interaction of d-tubocurarine analogs with the mouse nicotinic acetylcholine receptor. Ligand orientation at the binding site.
J. Biol. Chem. 272 , 24891-24898, (1997) The binding of d-tubocurarine and several of its analogs to the mouse nicotinic acetylcholine receptor (AChR) was measured by competition against the initial rate 125I-alpha-bungarotoxin binding to BC... |
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Acetylcholine receptor inhibition by d-tubocurarine involves both a competitive and a noncompetitive binding site as determined by stopped-flow measurements of receptor-controlled ion flux in membrane vesicles.
Biochemistry 25 , 1786, (1986) The issue of whether d-tubocurarine, the classical acetylcholine receptor inhibitor, inhibits the receptor by a competitive or noncompetitive mechanism has long been controversial. d-Tubocurarine, in ... |
MFCD00150157 |
(+)-tubocurarine chloride pentahydrate |