Nutlin-3b
Modify Date: 2024-01-02 11:58:13
Nutlin-3b structure
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Common Name | Nutlin-3b | ||
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| CAS Number | 675576-97-3 | Molecular Weight | 581.490 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C30H30Cl2N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nutlin-3bNutlin-3b is a MDM2/p53 antagonist or inhibitor with IC50 of 13.6 μM. Nutlin-3b is a less active enantiomer |
| Name | 4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one |
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| Synonym | More Synonyms |
| Description | Nutlin-3b is a MDM2/p53 antagonist or inhibitor with IC50 of 13.6 μM. Nutlin-3b is a less active enantiomer |
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| Related Catalog | |
| Target |
IC50: 13.6 μM (MDM2/p53) |
| In Vitro | Nutlin-3b is a 150-fold less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 antagonist or inhibitor, in comparison with more potent opposite (-)-enantiomer Nutlin-3a. It is useful as a negative control for non-Mdm2 related cellular activities. Nutlin-3b is useful as a negative control s for non-MDM2-related cellular activities. Nutlin-3a induces the expression of MDM2 and p21 (but not p53) only in cells with wild-type p53. Nutlin-3b has no effect regardless of the p53 status of the cells. Only the active enantiomer Nutlin-3a shows a potent antiproliferative activity and clear separation of potency between the cells harboring wild-type p53 and those harboring mutant p53. The potency of Nutlin-3b is much lower in the wild-type p53 cells and nearly identical to the potency of Nutlin-3a against the mutant p53 cells. After 48 hours of exposure to the Nutlin-3a, 45% of the cell population became TUNEL positive, but cells treated with the Nutlin-3b are indistinguishable from the untreated controls. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C30H30Cl2N4O4 |
| Molecular Weight | 581.490 |
| Exact Mass | 580.164429 |
| PSA | 86.96000 |
| LogP | 2.77 |
| Index of Refraction | 1.648 |
| Storage condition | -20℃ |
| UNII-FJA1772CVW |
| nutlin-3B |
| 4-({4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one |
| 2-Piperazinone, 4-[[4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- |
| Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one |
| nutlin 3 |
| 4-{[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinone |
| NUTLIN 3B |
| Nutlin (3b) |