4-Amino-2-(trifluoromethyl)benzonitrile

Modify Date: 2024-01-02 15:00:32

4-Amino-2-(trifluoromethyl)benzonitrile Structure
4-Amino-2-(trifluoromethyl)benzonitrile structure
Common Name 4-Amino-2-(trifluoromethyl)benzonitrile
CAS Number 654-70-6 Molecular Weight 186.134
Density 1.4±0.1 g/cm3 Boiling Point 294.5±40.0 °C at 760 mmHg
Molecular Formula C8H5F3N2 Melting Point 141-145 °C(lit.)
MSDS Chinese USA Flash Point 131.9±27.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 4-Amino-2-(trifluoromethyl)benzonitrile
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 294.5±40.0 °C at 760 mmHg
Melting Point 141-145 °C(lit.)
Molecular Formula C8H5F3N2
Molecular Weight 186.134
Flash Point 131.9±27.3 °C
Exact Mass 186.040482
PSA 49.81000
LogP 2.93
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.500
Storage condition Room temperature.

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S36-S45-S37/39-S26
RIDADR 3439
WGK Germany 3
Packaging Group III
Hazard Class 6.1
HS Code 2926909090

 Synthetic Route

~78%

4-Amino-2-(trifluoromethyl)benzonitrile Structure

4-Amino-2-(trif...

CAS#:654-70-6

Literature: AGOURON PHARMACEUTICALS, INC. Patent: EP365763 A1, 1990 ;

~%

4-Amino-2-(trifluoromethyl)benzonitrile Structure

4-Amino-2-(trif...

CAS#:654-70-6

Literature: Journal of the American Chemical Society, , vol. 76, p. 1051,1054

~76%

4-Amino-2-(trifluoromethyl)benzonitrile Structure

4-Amino-2-(trif...

CAS#:654-70-6

Literature: Jones, Terence R.; Varney, Michael D.; Webber, Stephen E.; Lewis, Kathleen K.; Marzoni, Gifford P.; Palmer, Cindy L.; Kathardekar, Vinit; Welsh, Katharine M.; Webber, Stephanie; Matthews, David A.; Appelt, Krzysztof; Smith, Ward W.; Janson, Cheryl A.; Villafranca; Bacquet, Russell J.; Howland, Eleanor F.; Booth, Carol L. J.; Herrmann, Steven M.; Ward, Robert W.; White, Jennifer; Moomaw, Ellen W.; Bartlett, Charlotte A.; Morse, Cathy A. Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 904 - 917

~%

4-Amino-2-(trifluoromethyl)benzonitrile Structure

4-Amino-2-(trif...

CAS#:654-70-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 7 p. 1860 - 1864

~%

4-Amino-2-(trifluoromethyl)benzonitrile Structure

4-Amino-2-(trif...

CAS#:654-70-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 7 p. 1860 - 1864

~%

4-Amino-2-(trifluoromethyl)benzonitrile Structure

4-Amino-2-(trif...

CAS#:654-70-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 7 p. 1860 - 1864

~%

4-Amino-2-(trifluoromethyl)benzonitrile Structure

4-Amino-2-(trif...

CAS#:654-70-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 7 p. 1860 - 1864

 Customs

HS Code 2926909090
Summary HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

Bicalutamide intermediate F
2-CYANO-5-AMINOBENZOTRIFLUORIDE
5-AMINO-2-CYANO BENZOTRIFLUORID
MFCD00042155
4-amino-2-trifluoromethyl-benzonitrile
4-Cyano-3-Trifluoromethylanili
5-AMINO-2-CYANOBENZOTRIFLUORIDE
BUTTPARK 22 1-63
4-amino-2-trifluoromethylbenzonittrile
3-Amino-6-cyanobenzotrifluoride
Bicalutamide Impurity 6