Cytidine

Modify Date: 2024-01-02 14:21:41

Cytidine Structure
Cytidine structure
 Common Name Cytidine
CAS Number 65-46-3 Molecular Weight 243.217
Density 1.9±0.1 g/cm3 Boiling Point 529.7±60.0 °C at 760 mmHg
Molecular Formula C9H13N3O5 Melting Point 210-220 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 274.1±32.9 °C

 Use of Cytidine


Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.Target: Nucleoside antimetabolite/analogCytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. Cytidine is a component of RNA. If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine. Dietary sources of cytidine include foods with high RNA (ribonucleic acid) content, such as organ meats, Brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine), which are absorbed intact. In humans, dietary cytidine is converted into uridine, which is probably the compound behind cytidine's metabolic effects.There are a variety of cytidine analogs with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, and zebularine exists in E. coli and is being examined for chemotherapy. Low doses of azacitidine and its analog decitabine have shown results against cancer through epigenetic demethylation.

 Names

Name Cytidine
Synonym More Synonyms

 Cytidine Biological Activity

Description Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.Target: Nucleoside antimetabolite/analogCytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. Cytidine is a component of RNA. If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine. Dietary sources of cytidine include foods with high RNA (ribonucleic acid) content, such as organ meats, Brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine), which are absorbed intact. In humans, dietary cytidine is converted into uridine, which is probably the compound behind cytidine's metabolic effects.There are a variety of cytidine analogs with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, and zebularine exists in E. coli and is being examined for chemotherapy. Low doses of azacitidine and its analog decitabine have shown results against cancer through epigenetic demethylation.
Related Catalog
Target

Human Endogenous Metabolite
References

[1]. Jonas DA, et al. Safety considerations of DNA in food. Ann Nutr Metab. 2001;45(6):235-54.

[2]. Wurtman RJ, et al. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol. 2000 Oct 1;60(7):989-92.

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 529.7±60.0 °C at 760 mmHg
Melting Point 210-220 °C (dec.)(lit.)
Molecular Formula C9H13N3O5
Molecular Weight 243.217
Flash Point 274.1±32.9 °C
Exact Mass 243.085526
PSA 130.83000
LogP -1.78
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.756
Water Solubility SOLUBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW7370000
CHEMICAL NAME :
2(1H)-Pyrimidinone, 4-amino-1-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
65-46-3
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C9-H13-N3-O5
MOLECULAR WEIGHT :
243.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
150 umol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9990 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F+
Risk Phrases R68
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UW7370000
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
EINECS 200-610-9
4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone
2(1H)-Pyrimidinone, 4-amino-1-β-D-ribofuranosyl-
1-β-D-Ribofuranosylcytosine
4-Amino-1-β-δ-ribofuranosyl-2(1H)-pyrimidinone
4-Amino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-on
MFCD02181091
Cytidine
4-Amino-1-b-D-ribofuranosyl-2(1H)-pyrimidinone
Cyd
Cytidin
1-β-D-ribofuranosyl-Cytosine
Citidine
1-(b-δ-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
Cytosine, 1-β-D-ribofuranosyl-
d-cytidine
1-β-δ-Ribofuranosylcytosine
CYTIDINE extrapure
1-b-D-Ribofuranosylcytosine
2-Pyrimidinol, 1,4-dihydro-4-imino-1-β-D-ribofuranosyl-
4-Imino-1-(β-D-ribofuranosyl)-1,4-dihydro-2-pyrimidinol
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  • Product Name: Cytidine
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  • Purity: 98.0%
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Related Compounds: More...
CYTIDINE 3
84-52-6
L-Cytidine
79017-19-9
L-Cytidine
7428-39-9
L-Cytidine
26524-60-7
ψ-cytidine
39030-19-8
Cytidine-d1
177978-30-2
CYTIDINE-D2
40632-25-5
Aracytidine
17283-91-9
Cytidine-13C
201996-57-8
Chemsrc provides Cytidine(CAS#:65-46-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Cytidine are included as well.>> amp version: Cytidine

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