L(-)-Carvone

Modify Date: 2024-01-02 16:22:15

L(-)-Carvone structure	Common Name	L(-)-Carvone
	CAS Number	6485-40-1	Molecular Weight	150.218
	Density	0.958	Boiling Point	227-230 ºC
	Molecular Formula	C₁₀H₁₄O	Melting Point	25.2ºC
	MSDS	Chinese USA	Flash Point	88 ºC
	Symbol	GHS07	Signal Word	Warning

Use of L(-)-Carvone

(-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae[1][2].

Name	(-)-carvone
Synonym	More Synonyms

Description	(-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	eel AChE:2.19 mM (Ki)
In Vitro	(-)-Carvone (3.04 mM; 30 min) inactivates eel AChE with Ki value of 2.19 mM[1].
In Vivo	(-)-Carvone (5% in absolute ethanol v/v, 20 μL; application to the thoraces ventral surfaces) inhibits AChE such as horse serum cholinesterase, house fly head cholinesterases, and head and thorax cholinesterases from the Madagascar roach in vitro[1]. (-)-Carvone (0.05%-0.1% w/v; p.o.; 7 d) inhibits E. insulana larvae growth, decreases weight of larvae[2]. Animal Model: Female roaches (Gromphadorhina portentosa) (6.4 g-6.8 g)[1] Dosage: 5% in absolute ethanol v/v, 20 μL Administration: Application to the ventral surfaces of their thoraces; decapitated and crude at various time intervals (0, 2, 4, 5, 20, 24, and 26 hr) Result: Inhibited the activity of AChE in the extracts of both the head and thorax.
References	[1]. Grundy D L, et al. Inhibition of acetylcholinesterases by pulegone-1, 2-epoxide[J]. Pesticide biochemistry and physiology, 1985, 23(3): 383-388. [2]. Meisner J, et al. The response of Earias insulana Boisd. larvae to phagodeterrent (–)‐carvone incorporated in an artificial diet 1[J]. Zeitschrift für Angewandte Entomologie, 1980, 90(1‐5): 80-82.

Density	0.958
Boiling Point	227-230 ºC
Melting Point	25.2ºC
Molecular Formula	C₁₀H₁₄O
Molecular Weight	150.218
Flash Point	88 ºC
Exact Mass	150.104462
PSA	17.07000
LogP	2.27
Vapour density	5.2 (vs air)
Vapour Pressure	0.1±0.5 mmHg at 25°C
Index of Refraction	1.481
Water Solubility	PRACTICALLY INSOLUBLE

L(-)-Carvone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS8650000

CHEMICAL NAME :: p-Mentha-6,8-dien-2-one, (R)-(-)-

CAS REGISTRY NUMBER :: 6485-40-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H14-O

MOLECULAR WEIGHT :: 150.24

WISWESSER LINE NOTATION :: L6V BUTJ B1 EY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1057,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02834

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 766 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1057,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8585 No. of Facilities: 459 (estimated) No. of Industries: 8 No. of Occupations: 39 No. of Employees: 19245 (estimated) No. of Female Employees: 10383 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	OS8650000
HS Code	29142900

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HS Code	2914299000
Summary	2914299000. other cyclanic, cyclenic or cyclotherpenic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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L(-)-Carvone

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: L(-)-Carvone
Price: ￥88.0/25ml ￥258.0/100ml
Purity: 99.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (-)-Carvone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L(-)-Carvone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 6485-40-1
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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