Shanzhiside methylester

Modify Date: 2024-01-02 22:40:55

Shanzhiside methylester Structure
Shanzhiside methylester structure
Common Name Shanzhiside methylester
CAS Number 64421-28-9 Molecular Weight 406.382
Density 1.6±0.1 g/cm3 Boiling Point 651.4±55.0 °C at 760 mmHg
Molecular Formula C17H26O11 Melting Point 90ºC (dec.)
MSDS N/A Flash Point 233.0±25.0 °C

 Use of Shanzhiside methylester


Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].

 Names

Name shanzhiside methyl ester
Synonym More Synonyms

 Shanzhiside methylester Biological Activity

Description Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].
Related Catalog
Target

IC50: GLP-1 receptor[1]

In Vivo Shanzhiside methyl ester exerts dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg[1].
References

[1]. Fan H, et al. Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.Neuropharmacology. 2016 Feb;101:98-109.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 651.4±55.0 °C at 760 mmHg
Melting Point 90ºC (dec.)
Molecular Formula C17H26O11
Molecular Weight 406.382
Flash Point 233.0±25.0 °C
Exact Mass 406.147522
PSA 175.37000
LogP -3.25
Vapour Pressure 0.0±4.4 mmHg at 25°C
Index of Refraction 1.621

 Safety Information

Safety Phrases 22-24/25

 Synonyms

Methyl (1S,4aS,5R,7S,7aS)-1-(β-D-glucopyranosyloxy)-5,7-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
shanziside Me-ester
shanziside methyl ester
shanzhiside methy ester
Shanzhiside methylester
Shanzhiside methyl ester
hanzhiside Methyl ester
Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5,7-dihydroxy-7-methyl-, methyl ester, (1S,4aS,5R,7S,7aS)-
Shaniside methyl ester
shanzhiside Me ester
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