Oxydiethan-2,1-diyldiacetat

Modify Date: 2024-01-02 21:46:31

Oxydiethan-2,1-diyldiacetat structure	Common Name	Oxydiethan-2,1-diyldiacetat
	CAS Number	628-68-2	Molecular Weight	190.194
	Density	1.1±0.1 g/cm3	Boiling Point	248.0±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₄O₅	Melting Point	19°C
	MSDS	USA	Flash Point	100.4±20.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of Oxydiethan-2,1-diyldiacetat

Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	diethylene glycol diacetate
Synonym	More Synonyms

Description	Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.1±0.1 g/cm3
Boiling Point	248.0±0.0 °C at 760 mmHg
Melting Point	19°C
Molecular Formula	C₈H₁₄O₅
Molecular Weight	190.194
Flash Point	100.4±20.4 °C
Exact Mass	190.084122
PSA	61.83000
LogP	-0.08
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.424

Oxydiethan-2,1-diyldiacetat MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AJ1800000

CHEMICAL NAME :: Acetic acid, oxydiethylene ester

CAS REGISTRY NUMBER :: 628-68-2

BEILSTEIN REFERENCE NO. :: 1777856

LAST UPDATED :: 199806

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H14-O5

MOLECULAR WEIGHT :: 190.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10700 uL/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1- 1975- Volume(issue)/page/year: 3,25,1977

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AJ1800000
HS Code	2918990090

Precursor 10
CAS#:108-24-7 Ethanoic anhydride CAS#:111-46-6 Diethylene glycol CAS#:123-91-1 1,4-Dioxane CAS#:64-19-7 acetic acid
CAS#:75-64-9 tert-Butylamine CAS#:127-09-3 Sodium acetate CAS#:111-44-4 Bis(chloroethyl... CAS#:141-78-6 ethyl acetate
CAS#:75-36-5 Acetyl chloride CAS#:463-51-4 ketene
DownStream 1
CAS#:73727-30-7 benzoic acid,2-...

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Diethyleneglycol diacetate

EINECS 211-049-4

Ethanol, 2,2'-oxybis-, diacetate

Diethylene glycol, diacetate (8CI)

Diethylene Glycol Diacetate

Oxydiethan-2,1-diyldiacetat

Oxydi-2,1-ethanediyl diacetate

Oxydiethane-2,1-diyl diacetate

MFCD00026211

DC Chemicals Limited
China
Product Name: Diethylene glycol diacetate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Diethylene glycol diacetate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Diethyleneglycol diacetate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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