DCEBIO

Modify Date: 2024-01-30 20:42:30

DCEBIO Structure
DCEBIO structure
Common Name DCEBIO
CAS Number 60563-36-2 Molecular Weight 231.08
Density 1.413g/cm3 Boiling Point N/A
Molecular Formula C9H8Cl2N2O Melting Point 209.5-210.5 °C
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of DCEBIO


DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells[1]. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance[2].

 Names

Name 5,6-dichloro-3-ethyl-1H-benzimidazol-2-one
Synonym More Synonyms

 DCEBIO Biological Activity

Description DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells[1]. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance[2].
Related Catalog
Target

Cl- secretion[1]

References

[1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64.

[2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.

 Chemical & Physical Properties

Density 1.413g/cm3
Melting Point 209.5-210.5 °C
Molecular Formula C9H8Cl2N2O
Molecular Weight 231.08
Exact Mass 230.00100
PSA 37.79000
LogP 2.65630
Index of Refraction 1.592

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles2

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Cell Physiol. Biochem. 37 , 1390-406, (2015)

Oxaliplatin (OXAL) is a third-generation organoplatinum which is effective against advanced cancer cells including glioma cells. How this agent and other related compounds interacts with ion channels ...

Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells.

Respir. Res. 10 , 120, (2009)

Secondhand smoke (SHS) exposure is an independent risk factor for asthma, rhinosinusitis, and more severe respiratory tract infections in children and adults. Impaired mucociliary clearance with subse...

 Synonyms

5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one
5,6-dichloro-1-ethyl-1,3-dihydro-benzoimidazol-2-one
DC-EBIO
5,6-dichloro-3-ethyl benzimidazolone
5,6-Dichlor-1-ethyl-benzimidazolon
5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
5,6-dichloro-1-ethyl-benzimidazolinone
Tocris-1422
5,6-Dichlor-2-oxo-1-ethyl-benzimidazolin
dichloro-EBIO
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