2,3-dinitrotoluene

Modify Date: 2024-01-04 19:19:22

2,3-dinitrotoluene Structure
2,3-dinitrotoluene structure
Common Name 2,3-dinitrotoluene
CAS Number 602-01-7 Molecular Weight 182.13400
Density 1.407 g/cm3 Boiling Point 331.5ºC at 760 mmHg
Molecular Formula C7H6N2O4 Melting Point 59-61 °C(lit.)
MSDS Chinese USA Flash Point 170.2ºC
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

 Names

Name 1-methyl-2,3-dinitrobenzene
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.407 g/cm3
Boiling Point 331.5ºC at 760 mmHg
Melting Point 59-61 °C(lit.)
Molecular Formula C7H6N2O4
Molecular Weight 182.13400
Flash Point 170.2ºC
Exact Mass 182.03300
PSA 91.64000
LogP 2.85780

 MSDS

Name: 2 3-Dinitrotoluene 99% Material Safety Data Sheet
Synonym: 1-Methyl-2,3-Dinitrobenzene
CAS: 602-01-7
Section 1 - Chemical Product MSDS Name:2 3-Dinitrotoluene 99% Material Safety Data Sheet
Synonym:1-Methyl-2,3-Dinitrobenzene

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
602-01-7 2,3-Dinitrotoluene 99 210-013-5
Hazard Symbols: T N
Risk Phrases: 23/24/25 45 48/22 62 50/53

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. May cause cancer. Harmful : danger of serious damage to health by prolonged exposure if swallowed. Possible risk of impaired fertility. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
May cause skin irritation. May cause cyanosis of the extremities.
Ingestion:
May cause irritation of the digestive tract. May cause liver damage.
Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. Overexposure may cause methemoglobinemia. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown blood. Inhalation can cause systemic acidosis and methemoglobinemia.
May cause liver damage.
Chronic:
Prolonged exposure may cause anemia and methemoglobinemia, characterized by dizziness, drowsiness, headache, breath shortness, cyanosis (bluish skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. May cause cancer according to animal studies. Chronic exposure may cause liver damage. There is a danger of cumulative effects.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Alcoholic beverage consumption may enhance the toxic effects of this substance. For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 602-01-7: CAS# 25321-14-6: United States OSHA: 1.5 mg/m3 TWA Belgium - TWA: 0.15 mg/m3 VLE Malaysia: 0.2 mg/m3 TWA Spain: 0.15 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystals
Color: light yellow
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 59.00 - 61.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C7H6N2O4
Molecular Weight: 182.14

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 602-01-7: XT1400000 CAS# 25321-14-6: XT1300000 LD50/LC50:
CAS# 602-01-7: Draize test, rabbit, skin: 500 mg/24H Mild; Oral, mouse: LD50 = 1072 mg/kg; Oral, rat: LD50 = 911 mg/kg.
CAS# 25321-14-6: Oral, mouse: LD50 = 750 mg/kg.
Carcinogenicity:
2,3-Dinitrotoluene - Not listed by ACGIH, IARC, or NTP.
Dinitrotoluene (mixed isomers) - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 5/1/96 Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Bluegill/Sunfish: 330ug/L; 96H; Static Other For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: DINITROTOLUENES
Hazard Class: 6.1
UN Number: 2038
Packing Group: II
IMO
Shipping Name: DINITROTOLUENES
Hazard Class: 6.1
UN Number: 2038
Packing Group: II
RID/ADR
Shipping Name: DINITROTOLUENES
Hazard Class: 6.1
UN Number: 2038
Packing group: II
USA RQ: CAS# 25321-14-6: 10 lb final RQ; 4.54 kg final RQ

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 45 May cause cancer.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 48/22 Harmful : danger of serious damage to health
by prolonged exposure if swallowed.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
R 62 Possible risk of impaired fertility.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 602-01-7: No information available.
CAS# 25321-14-6: No information available.
Canada
CAS# 602-01-7 is listed on Canada's NDSL List.
CAS# 25321-14-6 is listed on Canada's DSL List.
CAS# 602-01-7 is not listed on Canada's Ingredient Disclosure List.
CAS# 25321-14-6 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 602-01-7 is listed on the TSCA inventory.
CAS# 25321-14-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XT1400000
CHEMICAL NAME :
Toluene, 2,3-dinitro-
CAS REGISTRY NUMBER :
602-01-7
BEILSTEIN REFERENCE NO. :
2212428
LAST UPDATED :
199710
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C7-H6-N2-O4
MOLECULAR WEIGHT :
182.15
WISWESSER LINE NOTATION :
WNR B1 FNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
911 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1072 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - rat Liver
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982 Volume(issue)/page/year: 26OCT1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2,3-DINITROTOLUENE-air:10H CA TWA 1.5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

 Safety Information

Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H301 + H311 + H331-H341-H350-H361f-H373-H410
Precautionary Statements P201-P261-P273-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T: Toxic;N: Dangerous for the environment;
Risk Phrases R45
Safety Phrases S53-S45-S60-S61
RIDADR UN 3454 6.1/PG 2
WGK Germany 3
RTECS XT1400000
Packaging Group II
Hazard Class 6.1(a)

 Synthetic Route

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 Synonyms

2,3-Dinitrotoluol
Benzene,1-methyl-2,3-dinitro
2,3-DNT
1,3-dinitrotoluene
Toluene,2,3-dinitro
EINECS 210-013-5
2,3-DINITROTOLUENE
MFCD00007178
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