(3S)-3-Isobutyl-2,5-piperazinedione
Modify Date: 2024-01-08 10:14:43
(3S)-3-Isobutyl-2,5-piperazinedione structure
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Common Name | (3S)-3-Isobutyl-2,5-piperazinedione | ||
|---|---|---|---|---|
| CAS Number | 5845-67-0 | Molecular Weight | 170.209 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 442.9±38.0 °C at 760 mmHg | |
| Molecular Formula | C8H14N2O2 | Melting Point | 255ºC | |
| MSDS | USA | Flash Point | 207.4±26.9 °C | |
Use of (3S)-3-Isobutyl-2,5-piperazinedioneCyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2]. |
| Name | cyclo(-leu-gly) |
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| Synonym | More Synonyms |
| Description | Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2]. |
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| Related Catalog | |
| Target |
Dopamine Receptor |
| In Vivo | Cyclo(glycyl-L-leucyl) (8 mg/kg; 皮下给药) 在阿扑吗啡 (APO) 后 24 小时给予，可减弱由急性高剂量 APO (5 mg/kg; 皮下给药) 引起的 DA 受体超敏反应[1]。 Animal Model: Male Swiss-Webster mice, 20-25g[1] Dosage: 8 mg/kg Administration: SC; single dose given 24h after apomorphine (APO) Result: Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.). |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 442.9±38.0 °C at 760 mmHg |
| Melting Point | 255ºC |
| Molecular Formula | C8H14N2O2 |
| Molecular Weight | 170.209 |
| Flash Point | 207.4±26.9 °C |
| Exact Mass | 170.105530 |
| PSA | 58.20000 |
| LogP | -0.66 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.453 |
| L-Leucylglycine diketopiperazine |
| MORPHINE TOLERANCE PEPTIDE |
| (3S)-3-Isobutyl-2,5-piperazinedione |
| 2,5-Piperazinedione, 3-(2-methylpropyl)-, (3S)- |
| MORPHIN,TOLERANCE PEPTIDE |
| Cyclo(Leu-Gly) |
| 3-isobutylpiperazine-2,5-quinone |
| (3S)-3-Isobutylpiperazine-2,5-dione |