H-Gly-Sar-Sar-OH

Modify Date: 2024-01-16 19:29:45

H-Gly-Sar-Sar-OH Structure
H-Gly-Sar-Sar-OH structure
Common Name H-Gly-Sar-Sar-OH
CAS Number 57836-11-0 Molecular Weight 217.22200
Density 1.28g/cm3 Boiling Point 406.5ºC at 760 mmHg
Molecular Formula C8H15N3O4 Melting Point N/A
MSDS N/A Flash Point 199.6ºC

 Use of H-Gly-Sar-Sar-OH


H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation[1][2][3].

 Names

Name h-gly-sar-sar-oh

 H-Gly-Sar-Sar-OH Biological Activity

Description H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation[1][2][3].
Related Catalog
In Vivo H-Gly-Sar-Sar-OH (0.1 mM;灌注;单剂量) 在 Sprague-Dawley 大鼠肾脏中未显著被水解 (给药 60 min) 或清除[2]。 H-Gly-Sar-Sar-OH (10 mg/kg;口服;单剂量) 在自发性高血压大鼠 (SHRs) 中显示出稳定性[3]。 H-Gly-Sar-Sar-OH 在自发性高血压大鼠中的药代动力学 (PK) 参数[3] Week old Cmax (nmol/mL, plasma) Tmax (min) AUC0-90 min (nmol•min/mL, plasma) T1/2 (min) 8 4.6±0.6 30 258.0±32.1 75 40 10.7±1.5 30 621.0±86.3 83 Animal Model: Male Sprague-Dawley rats (350 g)[2]. Dosage: 0.1 mM. Administration: Perfusion (kidney); single dose. Result: Showed stability. Animal Model: Male SHRs (8 and 40 week-old)[3]. Dosage: 10 mg/kg. Administration: Oral gavage; single dose. Result: Detected in full form.
References

[1]. Hong SM, et al. Structural Design of Oligopeptides for Intestinal Transport Model. J Agric Food Chem. 2016 Mar 16;64(10):2072-9.  

[2]. Minami H, et al. Oligopeptides: mechanism of renal clearance depends on molecular structure. Am J Physiol. 1992 Jul;263(1 Pt 2):F109-15.  

[3]. Hanh VT, et al. Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. J Agric Food Chem. 2017 Jul 26;65(29):5935-5943.  

 Chemical & Physical Properties

Density 1.28g/cm3
Boiling Point 406.5ºC at 760 mmHg
Molecular Formula C8H15N3O4
Molecular Weight 217.22200
Flash Point 199.6ºC
Exact Mass 217.10600
PSA 103.94000
Index of Refraction 1.519