7-Hydroxy-4-(trifluoromethyl)coumarin

Modify Date: 2024-01-04 12:51:20

7-Hydroxy-4-(trifluoromethyl)coumarin Structure
7-Hydroxy-4-(trifluoromethyl)coumarin structure
Common Name 7-Hydroxy-4-(trifluoromethyl)coumarin
CAS Number 575-03-1 Molecular Weight 230.140
Density 1.6±0.1 g/cm3 Boiling Point 311.4±42.0 °C at 760 mmHg
Molecular Formula C10H5F3O3 Melting Point 178-180 °C(lit.)
MSDS Chinese USA Flash Point 142.2±27.9 °C
Symbol GHS06
GHS06
Signal Word Danger

 Use of 7-Hydroxy-4-(trifluoromethyl)coumarin


4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes[1].

 Names

Name 7-Hydroxy-4-(trifluoromethyl)coumarin
Synonym More Synonyms

 7-Hydroxy-4-(trifluoromethyl)coumarin Biological Activity

Description 4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes[1].
Related Catalog
References

[1]. Renwick AB, et, al. Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Xenobiotica. 2001 Dec;31(12):861-78.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 311.4±42.0 °C at 760 mmHg
Melting Point 178-180 °C(lit.)
Molecular Formula C10H5F3O3
Molecular Weight 230.140
Flash Point 142.2±27.9 °C
Exact Mass 230.019073
PSA 50.44000
LogP 2.88
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.546
Water Solubility DMF: soluble

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300-H315-H319-H335
Precautionary Statements P261-P264-P301 + P310-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R25;R36/37/38
Safety Phrases S26-S36-S45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
HS Code 2932209090

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

7-Hydroxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one
7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one
7-hydroxy-4-(trifluoromethyl)chromen-2-one
2H-1-Benzopyran-2-one, 7-hydroxy-4-(trifluoromethyl)-
MFCD00037578