[Nle11]-Substance P
![[Nle11]-Substance P Structure](https://image.chemsrc.com/caspic/019/57462-42-7.png)
[Nle11]-Substance P structure
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Common Name | [Nle11]-Substance P | ||
|---|---|---|---|---|
| CAS Number | 57462-42-7 | Molecular Weight | 1329.592 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C64H100N18O13 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of [Nle11]-Substance P[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems. |
| Name | arg-pro-lys-pro-gln-gln-phe-phe-gly-leu-nle-nh2 |
|---|---|
| Synonym | More Synonyms |
| Description | [Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems. |
|---|---|
| Related Catalog | |
| In Vitro | Substance P and its analog, [Nle11]-Substance P have shown similar potency in tests. The spasmogenic activity of Substance P and [Nle11]-Substance P are preserved in the same potency order on stimulated guinea-pig ileum[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C64H100N18O13 |
| Molecular Weight | 1329.592 |
| Exact Mass | 1328.771729 |
| PSA | 516.63000 |
| LogP | -0.18 |
| Index of Refraction | 1.654 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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In vitro activities of some synthetic substance P analogs.
Arch. Int. Pharmacodyn. Ther. 240 , 193, (1979) Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP... |
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Synthesis and biological activities of photoaffinity labeling analogues of substance P.
J. Med. Chem. 25 , 470, (1982) Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-actin... |
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Some observations indicating a low brain uptake of [3H]Nle11-Substance P.
Pharmazie 38(2) , 108-10, (1983) The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after in... |
| L-Norleucinamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- |
| substance P,NleNH2(11) |
| N-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide |
| Substance P,[Nle11] |
| [Nle11 ]-substance P |
| N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide |
| [Nle11]-Substance P |
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- Product Name: [Nle11]-Substance P ≥97%
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