[Nle11]-Substance P

Modify Date: 2024-01-07 12:53:04

[Nle11]-Substance P Structure
[Nle11]-Substance P structure
Common Name [Nle11]-Substance P
CAS Number 57462-42-7 Molecular Weight 1329.592
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C64H100N18O13 Melting Point N/A
MSDS USA Flash Point N/A

 Use of [Nle11]-Substance P


[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.

 Names

Name arg-pro-lys-pro-gln-gln-phe-phe-gly-leu-nle-nh2
Synonym More Synonyms

 [Nle11]-Substance P Biological Activity

Description [Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.
Related Catalog
In Vitro Substance P and its analog, [Nle11]-Substance P have shown similar potency in tests. The spasmogenic activity of Substance P and [Nle11]-Substance P are preserved in the same potency order on stimulated guinea-pig ileum[1].
References

[1]. Chipkin RE, et al. In vitro activities of some synthetic substance P analogs. Arch Int Pharmacodyn Ther. 1979 Aug;240(2):193-202.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C64H100N18O13
Molecular Weight 1329.592
Exact Mass 1328.771729
PSA 516.63000
LogP -0.18
Index of Refraction 1.654

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles4

More Articles
In vitro activities of some synthetic substance P analogs.

Arch. Int. Pharmacodyn. Ther. 240 , 193, (1979)

Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP...

Synthesis and biological activities of photoaffinity labeling analogues of substance P.

J. Med. Chem. 25 , 470, (1982)

Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-actin...

Some observations indicating a low brain uptake of [3H]Nle11-Substance P.

Pharmazie 38(2) , 108-10, (1983)

The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after in...

 Synonyms

L-Norleucinamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-
substance P,NleNH2(11)
N-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide
Substance P,[Nle11]
[Nle11 ]-substance P
N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide
[Nle11]-Substance P
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