Metoprolol Tartrate structure
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Common Name | Metoprolol Tartrate | ||
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CAS Number | 56392-17-7 | Molecular Weight | 342.41 | |
Density | N/A | Boiling Point | 398.6ºC at 760 mmHg | |
Molecular Formula | C17H28NO6 | Melting Point | 120ºC | |
MSDS | Chinese USA | Flash Point | 194.9ºC | |
Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger |
Use of Metoprolol TartrateMetoprolol is a cardioselective β1-adrenergic blocking agent.Target: β1- adrenergic ReceptorPatients took 50 mg metoprolol twice daily with weekly titration to response or 200 mg twice daily. beta(1)-adrenergic receptor polymorphisms are important determinants of antihypertensive response to metoprolol. In the future, codon 49 and 389 genotypes or beta(1)-adrenergic receptor haplotypes might be used to predict the diastolic blood pressure response to metoprolol in patients with hypertension [1]. Patients were studied at baseline and after each dose titration of metoprolol succinate (at 25, 50, 100, and 200 mg once/day) and immediate-release carvedilol (at 3.125, 6.25, 12.5, and 25 mg twice/day). As assessed by glucose AUC, there was no significant difference in the degree of beta(2)-blockade between metoprolol 200 mg and carvedilol 25 mg. In contrast to these data, the degree of beta(2)-blockade as assessed by potassium AUC was greater for carvedilol compared with metoprolol across all doses [2]. |
Name | rac Metoprolol Hemi (+)-Tartrate |
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Synonym | More Synonyms |
Description | Metoprolol is a cardioselective β1-adrenergic blocking agent.Target: β1- adrenergic ReceptorPatients took 50 mg metoprolol twice daily with weekly titration to response or 200 mg twice daily. beta(1)-adrenergic receptor polymorphisms are important determinants of antihypertensive response to metoprolol. In the future, codon 49 and 389 genotypes or beta(1)-adrenergic receptor haplotypes might be used to predict the diastolic blood pressure response to metoprolol in patients with hypertension [1]. Patients were studied at baseline and after each dose titration of metoprolol succinate (at 25, 50, 100, and 200 mg once/day) and immediate-release carvedilol (at 3.125, 6.25, 12.5, and 25 mg twice/day). As assessed by glucose AUC, there was no significant difference in the degree of beta(2)-blockade between metoprolol 200 mg and carvedilol 25 mg. In contrast to these data, the degree of beta(2)-blockade as assessed by potassium AUC was greater for carvedilol compared with metoprolol across all doses [2]. |
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Related Catalog | |
References |
Boiling Point | 398.6ºC at 760 mmHg |
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Melting Point | 120ºC |
Molecular Formula | C17H28NO6 |
Molecular Weight | 342.41 |
Flash Point | 194.9ºC |
PSA | 216.50000 |
LogP | 1.88560 |
Stability | Stable. Incompatible with strong oxidizing agents. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS02, GHS06, GHS08 |
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Signal Word | Danger |
Hazard Statements | H225-H301 + H311 + H331-H370 |
Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
Hazard Codes | F,T |
Risk Phrases | 11-23/24/25-39/23/24/25 |
Safety Phrases | 7-16-36/37-45 |
RIDADR | NONH for all modes of transport |
RTECS | UB7450100 |
~72% Metoprolol Tartrate CAS#:56392-17-7 |
Literature: IPCA LABORATORIES LIMITED Patent: WO2005/46568 A2, 2005 ; Location in patent: Page/Page column 9-10 ; |
Precursor 2 | |
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DownStream 0 |
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UNII:W5S57Y3A5L |
Metoprolol tartrate |
MFCD00941460 |
(2R,3R)-2,3-Dihydroxysuccinic acid - 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol (1:2) |
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2) |
(2R,3R)-2,3-Dihydroxysuccinic acid - 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol (1:2) |
EINECS 260-148-9 |
(±)-Metoprolol (+)-tartrate salt |
Metoprolol (Tartrate) |