UNII:C19D0413EL

Modify Date: 2024-01-11 22:02:45

UNII:C19D0413EL structure	Common Name	UNII:C19D0413EL
	CAS Number	56392-16-6	Molecular Weight	283.363
	Density	1.1±0.1 g/cm3	Boiling Point	437.6±45.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₅NO₄	Melting Point	65-67ºC
	MSDS	USA	Flash Point	218.4±28.7 °C

Use of UNII:C19D0413EL

a-Hydroxymetoprolol is a metabolite of metoprolol. The adrenoreceptor blocking effect of a-Hydroxymetoprolol on metoprolol is almost zero[1].

Name	α-Hydroxy Metoprolol
Synonym	More Synonyms

Description	a-Hydroxymetoprolol is a metabolite of metoprolol. The adrenoreceptor blocking effect of a-Hydroxymetoprolol on metoprolol is almost zero[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Hoffmann KJ, et al. The effect of impaired renal function on the plasma concentration and urinary excretion of metoprolol metabolites. Clin Pharmacokinet. 1980 Mar-Apr;5(2):181-91.

Density	1.1±0.1 g/cm3
Boiling Point	437.6±45.0 °C at 760 mmHg
Melting Point	65-67ºC
Molecular Formula	C₁₅H₂₅NO₄
Molecular Weight	283.363
Flash Point	218.4±28.7 °C
Exact Mass	283.178345
PSA	70.95000
LogP	0.72
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.524
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA4907000

CHEMICAL NAME :: Benzenemethanol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-alpha-( methoxymethyl)-

CAS REGISTRY NUMBER :: 56392-16-6

LAST UPDATED :: 198809

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H25-N-O4

MOLECULAR WEIGHT :: 283.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,186,1979

RIDADR	NONH for all modes of transport

3-[4-(methylacetyl)phenoxy]-1-(isopropylamino)-2-propanol structure

3-[4-(methylace...

CAS#:110458-45-2

~95%

UNII:C19D0413EL Structure

UNII:C19D0413EL

CAS#:56392-16-6

Literature: Shetty, H. Umesha; Nelson, Wendel L. Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 55 - 59

2-Bromo-4'-hydroxyacetophenone structure

2-Bromo-4'-hydr...

CAS#:2491-38-5

~%

UNII:C19D0413EL Structure

UNII:C19D0413EL

CAS#:56392-16-6

Literature: Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

1-(4-Hydroxyphenyl)-2-methoxyethanone structure

1-(4-Hydroxyphe...

CAS#:32136-81-5

~%

UNII:C19D0413EL Structure

UNII:C19D0413EL

CAS#:56392-16-6

Literature: Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

2-methoxy-1-[4-(oxiranylmethoxy)phenyl]ethanone structure

2-methoxy-1-[4-...

CAS#:110458-44-1

~%

UNII:C19D0413EL Structure

UNII:C19D0413EL

CAS#:56392-16-6

Literature: Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

3-[4-(methylacetyl)phenoxy]-1,2-propanediol structure

3-[4-(methylace...

CAS#:110458-43-0

~%

UNII:C19D0413EL Structure

UNII:C19D0413EL

CAS#:56392-16-6

Literature: Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

N/A structure

N/A

CAS#:110458-42-9

~%

UNII:C19D0413EL Structure

UNII:C19D0413EL

CAS#:56392-16-6

Literature: Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

Metoprolol structure

Metoprolol

CAS#:51384-51-1

~%

UNII:C19D0413EL Structure

UNII:C19D0413EL

CAS#:56392-16-6

Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442

Precursor 6
CAS#:110458-45-2 3-[4-(methylace... CAS#:2491-38-5 2-Bromo-4'-hydr... CAS#:32136-81-5 1-(4-Hydroxyphe... CAS#:110458-44-1 2-methoxy-1-[4-...
CAS#:110458-43-0 3-[4-(methylace... CAS#:51384-51-1 Metoprolol
DownStream 0

Simultaneous determination of metoprolol and α-hydroxymetoprolol in human plasma using excitation-emission matrix fluorescence coupled with second-order calibration methods.

Bioanalysis 4(23) , 2781-93, (2012)

Metoprolol (MET) is a β1-adrenoceptor antagonist, which is widely used in the treatment of cardiovascular diseases, and α-hydroxymetoprolol (α-OHM) is its hydroxylated metabolite. Owing to their simil...

Metoprolol oxidation polymorphism in Brazilian elderly cardiac patients.

J. Pharm. Pharmacol. 65(9) , 1347-53, (2013)

The purpose of this study was to phenotype the CYP2D6 in elderly with heart disease classified as extensive metabolizer or poor metabolizers (PM) of metoprolol, develop and validate the method of anal...

Variation of pharmacokinetics after oral administration of slow-release metoprolol tablets and pharmacogenetic considerations.

Arzneimittelforschung 42(6) , 802-6, (1992)

The maximum plasma concentrations (Cmax) after oral administration of 120 mg tablets of slow-release metoprolol (CAS 37350-58-6) to 75 Japanese healthy male volunteers and 15 arrhythmic patients were ...

1-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-3-(isopropylamino)-2-propanol

3-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-1-isopropylamino-2-propanol

Benzenemethanol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-α-(methoxymethyl)-

α-HYDROXYMETOPROLOL

1-[4-(1-hydroxy-2-methoxyethyl)phenoxy]-3-(isopropylamino)propan-2-ol

UNII:C19D0413EL

DC Chemicals Limited
China
Product Name: α-hydroxy Metoprolol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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