Ethyl [(4-methylphenyl)sulfonyl]carbamate

Modify Date: 2024-01-02 12:06:37

Ethyl [(4-methylphenyl)sulfonyl]carbamate structure	Common Name	Ethyl [(4-methylphenyl)sulfonyl]carbamate
	CAS Number	5577-13-9	Molecular Weight	243.279
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₃NO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ethyl [(4-methylphenyl)sulfonyl]carbamate

Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

Name	Ethyl N-(4-methylphenyl)sulfonylcarbamate
Synonym	More Synonyms

Description	Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27. [2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478. [3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

Description

Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

Related Catalog

Research Areas >> Metabolic Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

References

[1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27.

[2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478.

[3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

Density	1.3±0.1 g/cm3
Molecular Formula	C₁₀H₁₃NO₄S
Molecular Weight	243.279
Exact Mass	243.056534
PSA	80.85000
LogP	1.86
Index of Refraction	1.530

Hazard Codes	Xi
HS Code	2935009090

Ethyl chloroformate

CAS#:541-41-3

4-Toluenesulfonamide

CAS#:70-55-3

~88%

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Xi, Pin-xian; Xu, Zhi-hong; Liu, Xiao-hui; Cheng, Feng-juan; Zeng, Zheng-zhi Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 71, # 2 p. 523 - 528 Title/Abstract Full Text View citing articles Show Details Xi, Pin-Xian; Xu, Zhi-Hong; Liu, Xiao-Hui; Chen, Feng-Juan; Huang, Liang; Zeng, Zheng-Zhi Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 541 - 546

p-Toluenesulfon...

CAS#:4083-64-1

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: US5326796 A1, ;

1,3-bis-(4-meth...

CAS#:5219-81-8

Ethyl carbonate

CAS#:105-58-8

~91%

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Guo, Xiaoguang; Shang, Jianpeng; Li, Jian; Wang, Liguo; Ma, Yubo; Shi, Feng; Deng, Youquan Synthetic Communications, 2011 , vol. 41, # 8 p. 1102 - 1111

4-Toluenesulfonamide

CAS#:70-55-3

Hexamethylphosp...

CAS#:1608-26-0

~33%

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Bittner, Shmuel; Assaf, Yonit; Krief, Penina; Pomerantz, Martin; Ziemnicka, Barbara T.; Smith, Christina G. Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1712 - 1718

P-TOLUENESULFIN...

CAS#:10439-23-3

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

p-Toluol-(-N-ca...

CAS#:93506-31-1

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

Precursor 7
CAS#:541-41-3 Ethyl chloroformate CAS#:70-55-3 4-Toluenesulfonamide CAS#:4083-64-1 p-Toluenesulfon... CAS#:5219-81-8 1,3-bis-(4-meth...
CAS#:105-58-8 Ethyl carbonate CAS#:1608-26-0 Hexamethylphosp... CAS#:10439-23-3 P-TOLUENESULFIN...
DownStream 7
CAS#:4083-64-1 p-Toluenesulfon... CAS#:28490-28-0 3-Pentenamide,4... CAS#:28490-61-1 2-Butenamide,3-... CAS#:28490-23-5 Benzenesulfonam...
CAS#:70-55-3 4-Toluenesulfonamide CAS#:32234-75-6 1-(4-methylphen... CAS#:664-95-9 Benzenesulfonam...

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Tosylcarbamic acid ethyl ester

Ethyl [(4-methylphenyl)sulfonyl]carbamate

ethyl N-(4-toluenesulfonyl)carbamate

ethyl tosylcarbaMate

Ethyl [(4-methylphenyl)sulphonyl]carbamate

Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester

Tosylurethane

ethoxycarbonamide of p-toluenebenzenesulfoacid

ethyl p-tosylcarbamate

(toluene-4-sulfonyl)-carbamic acid ethyl ester

ethyl N-(tosyl)carbamate

Carbamic acid, [(4-methylphenyl)sulfonyl]-, ethyl ester

N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester

2OVMSWR D1

N-(p-Tolylsulfonyl)carbamic acid ethyl ester

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ethyl [(4-methylphenyl)sulfonyl]carbamate
Price: ￥408.0/250mg ￥978.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Ethyl tosylcarbamate
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethyl N-(4-methylphenyl)sulfonylcarbamate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Ethyl N-(4-methylphenyl)sulfonylcarbamate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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