Lignoceric acid

Modify Date: 2024-01-03 22:34:55

Lignoceric acid Structure
Lignoceric acid structure
Common Name Lignoceric acid
CAS Number 557-59-5 Molecular Weight 368.637
Density 0.9±0.1 g/cm3 Boiling Point 405.9±8.0 °C at 760 mmHg
Molecular Formula C24H48O2 Melting Point 80-82 °C
MSDS Chinese USA Flash Point 182.2±13.3 °C

 Use of Lignoceric acid


Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].

 Names

Name lignoceric acid
Synonym More Synonyms

 Lignoceric acid Biological Activity

Description Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Heat flux induced by lignoceric acid in HepG2 peroxisomes was exothermic, indicating normal peroxisomal metabolism[1].
References

[1]. Anna Petroni, et al. Thermogenic flux induced by lignoceric acid in peroxisomes isolated from HepG2 cells and from X-adrenoleukodystrophy and control fibroblasts. J Cell Physiol. 2019 Aug;234(10):18344-18348.

[2]. J M Bourre, et al. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). Eur J Biochem. 1977 Jan 3;72(1):41-7.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 405.9±8.0 °C at 760 mmHg
Melting Point 80-82 °C
Molecular Formula C24H48O2
Molecular Weight 368.637
Flash Point 182.2±13.3 °C
Exact Mass 368.365417
PSA 37.30000
LogP 11.40
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.460
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany -

 Synthetic Route

 Articles45

More Articles
HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Development and application of a comparative fatty acid analysis method to investigate voriconazole-induced hepatotoxicity.

Clin. Chim. Acta 438 , 126-34, (2014)

As fatty acids play an important role in biological regulation, the profiling of fatty acid expression has been used to discover various disease markers and to understand disease mechanisms. This stud...

 Synonyms

Lignoceric acid
Tetracosanoic acid
EINECS 209-180-7
MFCD00002810
n-tetracosanoic acid
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