Pentagastrin

Modify Date: 2024-01-02 04:28:38

Pentagastrin Structure
Pentagastrin structure
 Common Name Pentagastrin
CAS Number 5534-95-2 Molecular Weight 767.891
Density 1.3±0.1 g/cm3 Boiling Point 1196.6±65.0 °C at 760 mmHg
Molecular Formula C37H49N7O9S Melting Point 229-230° (dec)
MSDS Chinese USA Flash Point 677.5±34.3 °C

 Use of Pentagastrin


pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally，which can cause the secretion and synthesis of salivary proteins.[1]In vivo: WIN55, 212-2, which is a non-selective cannabinoid agonist decreased gastric acid secretion stimulated by pentagastrin (10 mg/kg, i.v.) in anaesthetized rats.[2]The effect of curcumin administered i.g. in a dose of 50 mg/kg on the pentagastrin (250 ?g/kg)-stimulated gastric acid output in rats with chronic gastric fistula. [3]

 Names

Name pentagastrin
Synonym More Synonyms

 Pentagastrin Biological Activity

Description pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally，which can cause the secretion and synthesis of salivary proteins.[1]In vivo: WIN55, 212-2, which is a non-selective cannabinoid agonist decreased gastric acid secretion stimulated by pentagastrin (10 mg/kg, i.v.) in anaesthetized rats.[2]The effect of curcumin administered i.g. in a dose of 50 mg/kg on the pentagastrin (250 ?g/kg)-stimulated gastric acid output in rats with chronic gastric fistula. [3]
Related Catalog
References

[1]. Loy F et al. Ultrastructural evidence of a secretory role for melatonin in the human parotid gland.J Physiol Pharmacol, 2015 Dec, 66(6):847-53.

[2]. Abdel-Salam O et al. Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids. Asian Pac J Trop Med, 2016 May, 9(5):413-9.

[3]. Czekaj R et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol, 2016 Apr, 67(2):261-75.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1196.6±65.0 °C at 760 mmHg
Melting Point 229-230° (dec)
Molecular Formula C37H49N7O9S
Molecular Weight 767.891
Flash Point 677.5±34.3 °C
Exact Mass 767.331238
PSA 276.21000
LogP 3.03
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.604
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY2970000
CHEMICAL NAME :
Alaninamide, N-carboxy-beta-alanyl-L-tryptophyl-L-methionyl-L-aspa rtylphenyl-, N-tert-butyl ester, L-
CAS REGISTRY NUMBER :
5534-95-2
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C37-H49-N7-O9-S
MOLECULAR WEIGHT :
767.99

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
5 ug/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 289,470,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,612,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,776,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,766,1982

 Safety Information

Hazard Codes T
Risk Phrases 61-36/38-20/21
Safety Phrases S53-S45-S36/37/39-S22
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS AY2970000

 Articles34

More Articles
Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell.

Pflugers Arch. 463(3) , 419-27, (2012)

The vacuolar-type H-ATPase (V-ATPase) plays an important role in the active acidification of intracellular organelles. In certain specialized cells, such as the renal intercalated cell, apical V-ATPas...
Functional and histologic assessment of rat gastric mucosa after chronic treatment with sulphurous thermal water.

Pharmacology 85(3) , 146-52, (2010)

The effect of a chronic (4 weeks) administration of sulphurous thermal water on gastric acid secretion and mucosal defense was investigated in rats. Animals were randomized to receive daily intake of ...
Failure of pentagastrin-stimulated calcitonin testing in early manifestation of familial medullary thyroid cancer.

Wien. Klin. Wochenschr. 124(19-20) , 723-4, (2012)

This case report describes three generations of a family with familial medullary thyroid cancer (RET gene mutation L790F). One of the three siblings-all of them carrier of the respective mutation-exhi...

 Synonyms

pentagastrine
Pentagastrin
petogasrin
GRP
Gastrodiagnost
ay6608
N-(tert-Butoxycarbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
EINECS 226-889-7
N-Carboxy-β-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide N-tert-butyl ester
Peptavlon
petavlon
MFCD00076515
L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
N-[N-[N-[N-(N-tert-Butoxycarbonyl-b-alanyl)-L-tryptophanyl]-L-methionyl ]-L-aspartyl]-L-phenylalaninamide
N-(a-Carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3-ylpropionamido]-4-(methylthio)butyramido]succinamic Acid-N-tert-Butyl Ester
N-Carboxy-b-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide N-tert-Butyl Ester
lanineamide
N-[(1,1-Dimethylethoxy)carbonyl]-b-alanyl-L-tryptophyl-L-methionyl-L-a-aspartyl-L-phenylalaninamide
L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
Boc-β-ala-try-met-asp-phe(nh2)
Boc-b-Ala-Try-Met-Asp-Phe(NH2)
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Related Compounds: More...
des-Boc-Pentagastrin
21880-05-7
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57448-84-7
(ortho-nitrophenyl)sulfenyl pentagastrin
72957-43-8
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