4-(4-Hydroxyphenyl)-2-butanone

Modify Date: 2024-01-02 01:12:33

4-(4-Hydroxyphenyl)-2-butanone structure	Common Name	4-(4-Hydroxyphenyl)-2-butanone
	CAS Number	5471-51-2	Molecular Weight	164.201
	Density	1.1±0.1 g/cm3	Boiling Point	292.2±15.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂O₂	Melting Point	81-85 °C(lit.)
	MSDS	Chinese USA	Flash Point	122.9±13.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-(4-Hydroxyphenyl)-2-butanone

Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.

Name	raspberry ketone
Synonym	More Synonyms

Description	Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Phenols Research Areas >> Cardiovascular Disease
Target	PPAR-α
In Vitro	Raspberry ketone (1, 10, 20, and 50 μM) suppresses adipogenesis and lipid accumulation in 3T3-L1 pre-adipocytes. Raspberry ketone (10 µM) significantly blocks C/EBPα, PPARγ, and aP2 expression and increases the expression of ATGL and HSL, and CPT1B[1].
In Vivo	Raspberry ketone (0.5%, 1%, or 2%) increasses the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol contents (LDL-C), ISI (insulin-sensitivr index), PPAR-α and LDLR, decreases the serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), IRI (insulin resistance index), GLU (glucose), INS (insulin-sensitivr index), LEP (leptin), and TNF-α in rats compared with a high-fat diet-induced NASH model. Raspberry ketone also causes increased SOD activities[2]. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity[3].
Cell Assay	For the cytotoxicity study, 3T3-L1 pre-adipocytes are cultured and differentiated. After Raspberry ketone treatment for 4 d in DMEM containing 10% fetal bovine serum, the lactate dehydrogenase (LDH) concentration in the medium is immediately detected with the CytoTox 96 nonradioactive cytotoxicity assay kit[1].
Animal Admin	During the experimental period, the animal room holds four rats per cage, with free access to water and food, under conditions of temperature controlled at 20-26°C, humidity at 40-70%, and a 12/12-h day-night light cycle. Rats are fed with normal diet for 1 week and then randomly divided into five groups: normal control (NC) group (n=8) fed normal diet for 8 weeks, the model control (MC) group (n=8) fed high-fat diet (82% standard diet, 8.3% yolk powder, 9.0% lard, 0.5% cholesterol, and 0.2% sodium taurocholate), the Raspberry ketone low-dose (RKL) group (n=8), the Raspberry ketone middle-dose (RKM) group (n=8), and the Raspberry ketone high-dose (RKH) group (n=8). Rats are first fed with high-fat diet for 4 weeks, and then these rats are given intragastrically 0.5%, 1%, or 2% Raspberry ketone. The first two groups of rats are intragastrically administered salad oil at the same dose (2 mL/day per rat) once a day at 10:00 a.m., lasting for 4 weeks[2].
References	[1]. Park KS. Raspberry ketone, a naturally occurring phenolic compound, inhibits adipogenic and lipogenic gene expression in 3T3-L1 adipocytes. Pharm Biol. 2015 Jun;53(6):870-5. [2]. Wang L, et al. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food. 2012 May;15(5):495-503. [3]. Khan V, et al. Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats. Life Sci. 2018 Feb 1;194:205-212.

Density	1.1±0.1 g/cm3
Boiling Point	292.2±15.0 °C at 760 mmHg
Melting Point	81-85 °C(lit.)
Molecular Formula	C₁₀H₁₂O₂
Molecular Weight	164.201
Flash Point	122.9±13.0 °C
Exact Mass	164.083725
PSA	37.30000
LogP	0.94
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.535
Storage condition	Refrigerator

4-(4-Hydroxyphenyl)-2-butanone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL8925000

CHEMICAL NAME :: 2-Butanone, 4-(p-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 5471-51-2

BEILSTEIN REFERENCE NO. :: 0776080

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H12-O2

MOLECULAR WEIGHT :: 164.22

WISWESSER LINE NOTATION :: QR D2V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - analgesia

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,349,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - analgesia

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,349,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4912 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 13 No. of Employees: 3245 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4912 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	EL8925000
HS Code	2914501100

Precursor 10
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DownStream 9
CAS#:101268-32-0 2-[4-(3-hydroxy... CAS#:104-20-1 p-Methoxybenzyl... CAS#:38963-94-9 Raspberryketone... CAS#:3572-06-3 Cuelure
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CAS#:522617-84-1 4-(4-trimethyls...

HS Code	2914501100
Summary	HS: 2914501100. 4-(4-hydroxyphenyl)butan-2-one. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tarrif:5.5%. general tariff:30.0%

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Oxyphenalon

4-hydroxy benzyl acetone

Raspberry keton

4-(4-Hydroxyphenyl)-2-butanone

Frambinone

Rheosmin

OXYPHENONE

OXYPHENYLON

Raspberry ketone

EINECS 226-806-4

RASBERRY KETONE

MFCD00002394

p-Hydroxy benzylacetone

FEMA 2588

OXANONE

BioBioPha
China
Product Name: 4-(4-Hydroxyphenyl)-2-butanone
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
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Price: ￥138.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 4-(4-Hydroxyphenyl)-2-butanone
Price: $280.0/20mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Raspberry ketone
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: 4- (4-Hydroxyphenyl) -2-Butanone
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Raspberry Ketone
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Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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