Sinapic acid

Modify Date: 2024-01-02 18:12:33

Sinapic acid structure	Common Name	Sinapic acid
	CAS Number	530-59-6	Molecular Weight	224.210
	Density	1.3±0.1 g/cm3	Boiling Point	403.4±40.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₂O₅	Melting Point	203-205 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	158.6±20.8 °C
	Symbol	GHS07	Signal Word	Warning

Use of Sinapic acid

Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1], and also inhibits ACE-I activity[2]. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells[1]. Sinapinic acid shows antioxidant and antidiabetic activities[2]. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats[3].

Name	trans-sinapic acid
Synonym	More Synonyms

Description	Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1], and also inhibits ACE-I activity[2]. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells[1]. Sinapinic acid shows antioxidant and antidiabetic activities[2]. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats[3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cancer Research Areas >> Metabolic Disease Natural Products >> Phenols
Target	HDAC:2.27 mM (IC50) ACE-I
In Vitro	Sinapinic acid acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1]. Sinapinic acid also inhibits ACE-I activity[2]. Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC50s of 0.91 ± 0.02 mM and 1.6 ± 0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells[1].
In Vivo	Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats[3].
References	[1]. Senawong T, et al. Histone deacetylase (HDAC) inhibitory and antiproliferative activities of phenolic-rich extracts derived from the rhizome of Hydnophytum formicarum Jack.: sinapinic acid acts as HDAC inhibitor. BMC Complement Altern Med. 2013 Sep 22;13:232. [2]. Quinn L, et al. Extraction and Quantification of Sinapinic Acid from Irish Rapeseed Meal and Assessment of Angiotensin-I Converting Enzyme (ACE-I) Inhibitory Activity. J Agric Food Chem. 2017 Aug 16;65(32):6886-6892. [3]. Zych M, et al. The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats. Oxid Med Cell Longev. 2018 Jun 4;2018:9274246.

Density	1.3±0.1 g/cm3
Boiling Point	403.4±40.0 °C at 760 mmHg
Melting Point	203-205 °C (dec.)(lit.)
Molecular Formula	C₁₁H₁₂O₅
Molecular Weight	224.210
Flash Point	158.6±20.8 °C
Exact Mass	224.068466
PSA	75.99000
LogP	1.29
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.604
Stability	Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.
Water Solubility	insoluble

Sinapic acid MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2918990090

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HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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trans-3,5-Dimethoxy-4-hydroxycinnamic Acid

trans-sinapic acid

BioBioPha
China
Product Name: Sinapic acid
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sinapic acid
Price: ￥178.0/20mg ￥208.0/5g ￥538.0/25g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Sinapinic acid (Sinapic acid)
Price: $50.0/100mg $100.0/250mg $200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxy-3,5-dimethoxycinnamic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥770/10 mM * 1 mL in DMSO

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