2-Aminoethyl Diphenylborinate

Modify Date: 2024-01-04 16:12:51

2-Aminoethyl Diphenylborinate structure	Common Name	2-Aminoethyl Diphenylborinate
	CAS Number	524-95-8	Molecular Weight	225.094
	Density	1.0±0.1 g/cm3	Boiling Point	325.3±34.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₆BNO	Melting Point	192-194 °C(lit.)
	MSDS	Chinese USA	Flash Point	150.6±25.7 °C

Use of 2-Aminoethyl Diphenylborinate

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[1][2][3].

Name	2-Aminoethyl Diphenylborinate
Synonym	More Synonyms

Description	2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Infection
References	[1]. Ma S, et al. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker MyocytesUsing the Calcium Imaging Technique. J Agric Food Chem. 2019 Nov 27. [2]. Boyacı MG, et al. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and OraiChannels in Subarachnoid Hemorrhage: An Experimental Study. [3]. Takahashi K, et al. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res. 2014 May 1;323(2):337-45.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Infection

References

[1]. Ma S, et al. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker MyocytesUsing the Calcium Imaging Technique. J Agric Food Chem. 2019 Nov 27.

[2]. Boyacı MG, et al. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and OraiChannels in Subarachnoid Hemorrhage: An Experimental Study.

[3]. Takahashi K, et al. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res. 2014 May 1;323(2):337-45.

Density	1.0±0.1 g/cm3
Boiling Point	325.3±34.0 °C at 760 mmHg
Melting Point	192-194 °C(lit.)
Molecular Formula	C₁₄H₁₆BNO
Molecular Weight	225.094
Flash Point	150.6±25.7 °C
Exact Mass	225.132492
PSA	35.25000
LogP	3.48
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.560
Storage condition	2-8°C

2-Aminoethyl Diphenylborinate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ED6150000

CHEMICAL NAME :: Borinic acid, O-(2-aminoethyl)diphenyl-

CAS REGISTRY NUMBER :: 524-95-8

BEILSTEIN REFERENCE NO. :: 2942273

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H16-B-N-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01899

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	ED6150000
HS Code	2931900090

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Precursor 9
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DownStream 8
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HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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Natural Product Reagent A

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EINECS 208-366-5

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MFCD00014823

(2-Aminoethoxy)diphenylborane

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Aminoethyl Diphenylborinate
Price: ￥168.0/1g ￥518.0/5g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 2-APB
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Borinic acid,B,B-diphenyl-, 2-aminoethyl ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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2-Aminoethyl Diphenylborinate

Use of 2-Aminoethyl Diphenylborinate

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