6-Methoxyluteolin

Modify Date: 2024-01-09 22:02:24

6-Methoxyluteolin structure	Common Name	6-Methoxyluteolin
	CAS Number	520-11-6	Molecular Weight	316.262
	Density	1.6±0.1 g/cm3	Boiling Point	659.1±55.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₂O₇	Melting Point	267ºC
	MSDS	N/A	Flash Point	250.9±25.0 °C

Use of 6-Methoxyluteolin

Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells[1][2].

Name	2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
Synonym	More Synonyms

Description	Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells[1][2].
Related Catalog	Signaling Pathways >> Others >> Others
In Vitro	Pretreatment with Nepetin dose-dependently inhibited IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43, 3.42 and 4.17 μM, respectively[1]. Nepetin (2.5-10 μM; 25 hours; ARPE-19 cells) treatment suppresses IL-1β-induced cytokine (IL-6, IL-8 and MCP-1) expression at mRNA level in ARPE-19 cells[1]. Nepetin (2.5-10 μM; 1.5 hours; ARPE-19 cells) treatment dose-dependently inhibits phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Nepetin decreases the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells[1]. RT-PCR[1] Cell Line: ARPE-19 cells Concentration: 2.5 μM, 5 μM, 10 μM Incubation Time: 25 hours Result: Suppressed the mRNA expression of IL-6, IL-8 and MCP-1 in ARPE-19 cells. Western Blot Analysis[1] Cell Line: ARPE-19 cells Concentration: 2.5 μM, 5 μM, 10 μM Incubation Time: 1.5 hours Result: Dose-dependently inhibited phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Decreased the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells.
References	[1]. Chen X, et al. Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells. Biomed Pharmacother. 2018 May;101:87-93. [2]. Militão GC, et al. Cytotoxic activity of nepetin, a flavonoid from Eupatorium ballotaefolium HBK. Pharmazie. 2004 Dec;59(12):965-6.

Density	1.6±0.1 g/cm3
Boiling Point	659.1±55.0 °C at 760 mmHg
Melting Point	267ºC
Molecular Formula	C₁₆H₁₂O₇
Molecular Weight	316.262
Flash Point	250.9±25.0 °C
Exact Mass	316.058289
PSA	120.36000
LogP	1.89
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.727

Hazard Codes	Xi
HS Code	2914509090

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

5,7,3',4'-Tetrahydroxy-6-methoxyflavone

Flavone, 3',4',5,7-tetrahydroxy-6-methoxy-

Nepetin

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one

3',4',5,7-Tetrahydroxy-6-methoxyflavone

6-METHOXYLUTEOLIN

Eupafolin

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one

BioBioPha
China
Product Name: 6-Methoxyluteolin
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 6-Methoxyluteolin
Price: ￥1768.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Nepetin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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6-Methoxyluteolin

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