PEG3-O-CH2COOH

Modify Date: 2024-01-06 18:34:31

PEG3-O-CH2COOH Structure
PEG3-O-CH2COOH structure
Common Name PEG3-O-CH2COOH
CAS Number 51951-05-4 Molecular Weight 208.21
Density N/A Boiling Point N/A
Molecular Formula C8H16O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PEG3-O-CH2COOH


PROTAC Linker 8 (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. SNIPER(ER)s contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. SNIPER(ER)s induce polyubiquitylation and proteasomal degradation of the target proteins in the cells[1].

 Names

Name PROTAC Linker 8

 PEG3-O-CH2COOH Biological Activity

Description PROTAC Linker 8 (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. SNIPER(ER)s contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. SNIPER(ER)s induce polyubiquitylation and proteasomal degradation of the target proteins in the cells[1].
Related Catalog
Target

Alkyl/ether

References

[1]. Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.

 Chemical & Physical Properties

Molecular Formula C8H16O6
Molecular Weight 208.21
Storage condition 2-8°C
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