Mimosine

Modify Date: 2024-01-02 16:47:32

Mimosine structure	Common Name	Mimosine
	CAS Number	500-44-7	Molecular Weight	198.18
	Density	1.544g/cm3	Boiling Point	428.6ºC at 760mmHg
	Molecular Formula	C₈H₁₀N₂O₄	Melting Point	224-228 °C
	MSDS	Chinese USA	Flash Point	213ºC
	Symbol	GHS07	Signal Word	Warning

Use of Mimosine

Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.

Name	l-mimosine
Synonym	More Synonyms

Description	Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology
In Vitro	Mimosine, a known chelator of Fe(III), may facilitate Fe(III) uptake in leucaena by serving as a phytosiderophore[2]. Mimosine, a bidentate iron-binding ligand, may also play a role in cellular translocation of iron within leucaena[2]. Mimosine is a toxic nonprotein amino acid that is a major constituent of the tropical legumesLeucaenaandMimosa[4]. Mimosine (400 μM), through iron chelation, reversibly blocks cell cycle progression in MDA-MB-453 human breast cancer cells[4]. Mimosine (400 μM) reduces DNA synthesis by greater than 90% of control within 4 hr of treatment, and suppresses total proline-directed protein kinase activity to less than 10% of control after 16 hr treatment[4].
In Vivo	Mimosine (30, and 60 mg/kg) decreases sperm concentration[5]. Animal Model: ICR male mice (6-8 weeks)[5] Dosage: 15, 30, or 60 mg/kg Administration: Injected (i.p.) for 7 consecutive days Result: Could significantly reduce sperm concentration as compared to the control or low dose mimosine group (15 mg/kg) at doses of 30 and 60 mg/kg.
References	[1]. Keiko Murakami, et al. Generation of reactive oxygen species by hydroxypyridone compound/iron complexes. Redox Rep. 2020 Dec;25(1):59-63. [2]. Michael D H Honda, et al. Mimosine facilitates metallic cation uptake by plants through formation of mimosine-cation complexes.Plant Mol Biol. 2020 Mar;102(4-5):431-445. [3]. MaherHallakMSc, et al. Mimosine Induces Apoptosis through Metal Ion Chelation, Mitochondrial Activation and Reactive Oxygen Species Production in Human Leukemic Cells. Blood.2004, Nov 16, 104 (11): 4481. [4]. K S Kulp, et al. Mimosine blocks cell cycle progression by chelating iron in asynchronous human breast cancer cells. Toxicol Appl Pharmacol. 1996 Aug;139(2):356-64. [5]. Pipatpong Kanla, et al. Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice. Int. J. Morphol., 36(2):507-512, 2018.

Density	1.544g/cm3
Boiling Point	428.6ºC at 760mmHg
Melting Point	224-228 °C
Molecular Formula	C₈H₁₀N₂O₄
Molecular Weight	198.18
Flash Point	213ºC
Exact Mass	198.06400
PSA	105.55000
Index of Refraction	1.645
Storage condition	2-8C

Mimosine MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	S22-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933399090

Precursor 4
CAS#:10182-48-6 3,4-Pyridinediol CAS#:5147-00-2 O-acetyl-L-serine CAS#:1121-23-9 3-hydroxy-4-pyridone CAS#:56-45-1 L-serine
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells.

Mol. Pharmacol. 87(3) , 513-24, (2015)

Iron is an essential cellular nutrient, being a critical cofactor of several proteins involved in cell growth and replication. Compared with normal cells, neoplastic cells have been shown to require a...

The novel function of JADE1S in cytokinesis of epithelial cells.

Cell Cycle 14 , 2821-34, (2015)

JADE1 belongs to a small family of PHD zinc finger proteins that interacts with histone acetyl transferase (HAT) HBO1 and is associated with chromatin. We recently reported JADE1 chromatin shuttling a...

Mimosine

(S)-2-amino-3-(3-hydroxy-4-oxo-4H-[1]pyridyl)-propionic acid

EINECS 207-905-1

leucenine

(S)-2-Amino-3-(3-hydroxy-4-oxo-4H-[1]pyridyl)-propionsaeure

(s)-1(4h)-pyridinepropanoicaci

MimosineLeucenol

MFCD00075909

L-Mimosine from Koa hoale seeds

L-LEUCININE

L(-)-MIMOSINE

LEUCENOL

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Mimosine
Price: ￥888.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: NSC 69188
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1(4H)-Pyridinepropanoicacid, a-amino-3-hydroxy-4-oxo-, (aS)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Mimosine

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