ORM-10103

Modify Date: 2024-01-10 09:03:29

ORM-10103 structure	Common Name	ORM-10103
	CAS Number	488847-28-5	Molecular Weight	348.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₆N₂O₄	Melting Point	N/A
	MSDS	USA	Flash Point	N/A
	Symbol	GHS06	Signal Word	Danger

Use of ORM-10103

ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively[1][2].

Name	5-nitro-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]pyridine

Description	ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	IC50: 55 (NCX -80 mV ), 67 nM (NCX 20 mV)[2]
References	[1]. Jost N, et al. ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart. Br J Pharmacol. 2013 Oct;170(4):768-78. [2]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041.

Molecular Formula	C₂₀H₁₆N₂O₄
Molecular Weight	348.35
Exact Mass	348.11100
PSA	77.17000
LogP	5.37160
Storage condition	2-8℃

ORM-10103 MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H413
Precautionary Statements	P301 + P310
RIDADR	UN 2811 6.1 / PGIII