Tabersonine

Modify Date: 2024-01-02 16:30:34

Tabersonine Structure
Tabersonine structure
 Common Name Tabersonine
CAS Number 4429-63-4 Molecular Weight 336.427
Density 1.3±0.1 g/cm3 Boiling Point 488.7±45.0 °C at 760 mmHg
Molecular Formula C21H24N2O2 Melting Point N/A
MSDS Chinese USA Flash Point 249.4±28.7 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Tabersonine


Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS[1].

 Names

Name tabersonine
Synonym More Synonyms

 Tabersonine Biological Activity

Description Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS[1].
Related Catalog
References

[1]. Zhang D, et al. Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination. Biochem Pharmacol. 2018 Aug;154:183-192.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 488.7±45.0 °C at 760 mmHg
Molecular Formula C21H24N2O2
Molecular Weight 336.427
Flash Point 249.4±28.7 °C
Exact Mass 336.183777
PSA 41.57000
LogP 3.57
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.652
Storage condition 2-8C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CJ0150000
CHEMICAL NAME :
Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetrahydro-, methyl ester, (5-alpha,12-beta, 19-alpha)-
CAS REGISTRY NUMBER :
4429-63-4
BEILSTEIN REFERENCE NO. :
0050163
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H24-N2-O2
MOLECULAR WEIGHT :
336.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 13,123,1955

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
RIDADR NONH for all modes of transport

 Synthetic Route

 Articles1

More Articles
Analysis of Indole Alkaloids from Rhazya stricta Hairy Roots by Ultra-Performance Liquid Chromatography-Mass Spectrometry.

Molecules 20 , 22621-34, (2015)

Rhazya stricta Decne. (Apocynaceae) contains a large number of terpenoid indole alkaloids (TIAs). This study focused on the composition of alkaloids obtained from transformed hairy root cultures of R....

 Synonyms

EINECS 224-615-0
(-)-Tabersonine
TABERSONINE
Methyl (5α,19α)-2,3,6,7-tetradehydroaspidospermidine-3-carboxylate
methyl 2,3,6,7-tetradehydro-5α,12β,19α-aspidospermidine-3-carboxylate
Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetradehydro-, methyl ester, (5α,19α)-
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Related Compounds: More...
tabersonine N-oxide
67249-34-7
19-Iodo-tabersonine
55856-70-7
Tabersonine hydrochloride
29479-00-3
Chemsrc provides Tabersonine(CAS#:4429-63-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tabersonine are included as well.>> amp version: Tabersonine

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