DT204
Modify Date: 2023-01-11 18:58:49
DT204 structure
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Common Name | DT204 | ||
|---|---|---|---|---|
| CAS Number | 428497-71-6 | Molecular Weight | 482.732 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 647.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C19H13BrClNO5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 345.3±34.3 °C | |
Use of DT204DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis; stablizes and increases p27 levels, does not increase the level of p53, demonstrates potential synergy with CI values of 0.7, 0.8 and 0.7 for RPMI8226, U266 and MM1.S respectively combined with 1 nM BTZ, co-treatment induces apoptosis in cells resistant to the proteasome inhibitors BTZ, carfilzomib or ixazomib; overcomes drug resistance and reduces the in vivo growth of myeloma tumors in murine models. |
| Name | (4-Bromo-2-{(Z)-[3-(4-chlorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)acetic acid |
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| Synonym | More Synonyms |
| Description | DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis; stablizes and increases p27 levels, does not increase the level of p53, demonstrates potential synergy with CI values of 0.7, 0.8 and 0.7 for RPMI8226, U266 and MM1.S respectively combined with 1 nM BTZ, co-treatment induces apoptosis in cells resistant to the proteasome inhibitors BTZ, carfilzomib or ixazomib; overcomes drug resistance and reduces the in vivo growth of myeloma tumors in murine models. |
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| References | References 1. Malek E, et al. Leukemia. 2017 Mar;31(3):645-653. View Related Products by Target E3 Ubiquitin Ligase |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 647.3±65.0 °C at 760 mmHg |
| Molecular Formula | C19H13BrClNO5S |
| Molecular Weight | 482.732 |
| Flash Point | 345.3±34.3 °C |
| Exact Mass | 480.938629 |
| LogP | 5.13 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.719 |
| (4-Bromo-2-{(Z)-[3-(4-chlorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)acetic acid |
| Acetic acid, 2-[4-bromo-2-[(Z)-[3-[(4-chlorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]- |