Prostaglandin D2

Modify Date: 2024-01-01 22:31:25

Prostaglandin D2 structure	Common Name	Prostaglandin D2
	CAS Number	41598-07-6	Molecular Weight	352.465
	Density	1.1±0.1 g/cm3	Boiling Point	549.6±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₃₂O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	300.3±26.6 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Prostaglandin D2

Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

Name	prostaglandin D2
Synonym	More Synonyms

Description	Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite
In Vivo	Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2]. Animal Model: Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1] Dosage: 5, 10, 20, or 50 pmol/min Administration: Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00 Result: Induced sleep-wake profiles.
References	[1]. Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. [2]. Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38(4):469-476. [3]. Kida T, et al. Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11(12):e0167729.

Density	1.1±0.1 g/cm3
Boiling Point	549.6±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.465
Flash Point	300.3±26.6 °C
Exact Mass	352.224976
PSA	94.83000
LogP	2.02
Vapour Pressure	0.0±3.4 mmHg at 25°C
Index of Refraction	1.561
Storage condition	20°C

Prostaglandin D2 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK7930000

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9-alpha,13E,15S)-

CAS REGISTRY NUMBER :: 41598-07-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H32-O5

MOLECULAR WEIGHT :: 352.52

WISWESSER LINE NOTATION :: T5VTJ B1U7 C2U4VQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 ug/kg

SEX/DURATION :: female 4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 5 mg/L/24H

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,1688,1986

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H360
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	60-22
Safety Phrases	S22;S26;S36;S53
RIDADR	NONH for all modes of transport
RTECS	UK7930000

Precursor 4
CAS#:101249-10-9 (5Z,13E)-9α-[(t... CAS#:61305-35-9 (R)-(-)-BENZOIN CAS#:85800-97-1 methyl 7-oxohep... CAS#:72522-67-9 (1E)-iodo-(3S)-...
DownStream 1
CAS#:62410-84-8 9ALPHA, 11ALPHA...

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

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Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

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Malva sylvestris is a species used worldwide as an alternative to anti-inflammatory therapies; however, its mechanism of action remains unknown. In this paper, the anti-inflammatory effects of M. sylv...

PGD2

(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid

Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)-

Prostaglandin D2

(5Z,9α,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid

MFCD00077857

DC Chemicals Limited
China
Product Name: Prostaglandin D2
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Purity: 98.0%
Stocking Period: 3 Day
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