Groenlandicine

Modify Date: 2024-01-10 07:38:04

Groenlandicine Structure
Groenlandicine structure
Common Name Groenlandicine
CAS Number 38691-95-1 Molecular Weight 321.32700
Density N/A Boiling Point N/A
Molecular Formula C19H16NO4+ Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Groenlandicine


Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2].

 Names

Name Dehydrocheilanthifoline
Synonym More Synonyms

 Groenlandicine Biological Activity

Description Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2].
Related Catalog
Target

Topoisomerase I

References

[1]. Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31(11):1405-12.

[2]. Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61(5):414-8.

 Chemical & Physical Properties

Molecular Formula C19H16NO4+
Molecular Weight 321.32700
Exact Mass 321.10000
PSA 48.64000
LogP 1.44980
Storage condition 2-8℃

 Synonyms

Benzo(a)-1,3-benzodioxolo(4,5-g)quinolizinium,11,12-dihydro-9-hydroxy-8-methoxy
Tetradehydrocheilanthiofolinium
Groenlandicine
Tetradehydrocheilanthifoline
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