Glafenine

Modify Date: 2024-01-02 23:04:27

Glafenine structure	Common Name	Glafenine
	CAS Number	3820-67-5	Molecular Weight	372.80200
	Density	1.428g/cm3	Boiling Point	618ºC at 760 mmHg
	Molecular Formula	C₁₉H₁₇ClN₂O₄	Melting Point	170℃
	MSDS	Chinese USA	Flash Point	327.6ºC

Use of Glafenine

Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins.

Name	glafenine
Synonym	More Synonyms

Description	Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology

Density	1.428g/cm3
Boiling Point	618ºC at 760 mmHg
Melting Point	170℃
Molecular Formula	C₁₉H₁₇ClN₂O₄
Molecular Weight	372.80200
Flash Point	327.6ºC
Exact Mass	372.08800
PSA	91.68000
LogP	3.21480
Index of Refraction	1.696

Glafenine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB2687000

CHEMICAL NAME :: Anthranilic acid, N-(7-chloro-4-quinolyl)-, 2,3-dihydroxypropyl ester

CAS REGISTRY NUMBER :: 3820-67-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H17-Cl-N2-O4

MOLECULAR WEIGHT :: 372.83

WISWESSER LINE NOTATION :: T66 BNJ EMR CVO1YQ1Q& IG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 34,377,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1486 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 38,847,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1343,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg/2D-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 34,309,1975

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CB2687000
HS Code	2933499090

4,7-Dichloroqui...

CAS#:86-98-6

α-Glyceryl Anth...

CAS#:71574-35-1

~75%

Glafenine

CAS#:3820-67-5

Literature: Mouzin; Cousse; Autin Synthesis, 1980 , vol. No. 1, p. 54 - 55

Isatoic anhydride

CAS#:118-48-9

Glafenine

CAS#:3820-67-5

Literature: Mouzin; Cousse; Autin Synthesis, 1980 , vol. No. 1, p. 54 - 55

Precursor 3
CAS#:86-98-6 4,7-Dichloroqui... CAS#:71574-35-1 α-Glyceryl Anth... CAS#:118-48-9 Isatoic anhydride
DownStream 2
CAS#:612-61-3 7-Chloroquinoline CAS#:71574-35-1 α-Glyceryl Anth...

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate

1-Glyceryl N-(7-chloro-4-quinolyl)anthranilate

2,3-Dihydroxypropyl 2-((7-chloroquinolin-4-yl)amino)benzoate

DC Chemicals Limited
China
Product Name: Glafenine
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Purity: 98.0%
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Glafenine

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