Flurocitabine

Modify Date: 2024-01-11 19:14:08

Flurocitabine structure	Common Name	Flurocitabine
	CAS Number	37717-21-8	Molecular Weight	243.19200
	Density	2.11g/cm3	Boiling Point	391.7ºC at 760mmHg
	Molecular Formula	C₉H₁₀FN₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	190.7ºC

Use of Flurocitabine

Flurocitabine is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine has antitumor activity during phase I studies in acute leukemia and solid tumors[1].

Name	Flurocitabine
Synonym	More Synonyms

Description	Flurocitabine is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine has antitumor activity during phase I studies in acute leukemia and solid tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Alberto P, et al. Phase II study of anhydro-ara-5-fluorocytidine in adenocarcinoma of gastrointestinal tract, epidermoid carcinoma of lung, head and neck, breast carcinoma and small cell anaplastic carcinoma of lung. A study report of the E.O.R.T.C. early clinical trial cooperative group. Eur J Cancer. 1978;14(2):195-201.

Density	2.11g/cm3
Boiling Point	391.7ºC at 760mmHg
Molecular Formula	C₉H₁₀FN₃O₄
Molecular Weight	243.19200
Flash Point	190.7ºC
Exact Mass	243.06600
PSA	100.59000
Index of Refraction	1.813

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5400000

CHEMICAL NAME :: Cytosine, 2,2'-anhydroarabino-5-fluoro-

CAS REGISTRY NUMBER :: 37717-21-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H10-F-N3-O4

MOLECULAR WEIGHT :: 243.22

WISWESSER LINE NOTATION :: T B556 AN CO GO IN HHTT&J D1Q EQ JZ KF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - normocytic anemia Blood - leukopenia

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,2657,1974

5-fluoro-arabino-O2,O2'-cyclocytidine

Ro-21-0702

fluoroancitabine

5-Fluoro-2,2'-cyclocytidine

5-fluoro-arabino-2,2'-anhydro-cytidine

Fluorocitabin

5-Fluor-2,2'-cyclocytidin

AAFC

DC Chemicals Limited
China
Product Name: Flurocitabine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Flurocitabine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Flurocitabine

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