BDBM32804

Modify Date: 2024-01-06 12:37:56

BDBM32804 structure	Common Name	BDBM32804
	CAS Number	37682-72-7	Molecular Weight	677.623
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₄₆Cl₂N₁₀O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of BDBM32804

Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4].

Name	Antipain dihydrochloride
Synonym	More Synonyms

Description	Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Metabolic Disease
In Vivo	The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4]. Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5].
References	[1]. DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53. [2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6. [3]. Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76. [4]. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626. [5]. Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757.

Molecular Formula	C₂₇H₄₆Cl₂N₁₀O₆
Molecular Weight	677.623
Exact Mass	676.297913
PSA	277.50000
LogP	4.25060
Storage condition	20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV9350800

CHEMICAL NAME :: L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-argin yl-N-(4-((amino iminomethyl)amino)-1-formylbutyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 37682-72-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H44-N10-O6.2Cl-H

MOLECULAR WEIGHT :: 677.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,263,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,263,1972

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
RTECS	YV9350800

Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.

Biochem. Pharmacol. 49 , 1236-47, (2010)

Usher syndrome is the major cause of deaf/blindness in the world. It is a genetic heterogeneous disorder, with nine genes already identified as causative for the disease. We noted expression of all kn...

Preparation of extracts from plants.

Meth. Enzymol. 182 , 174-193, (1990)

Maintaining protein stability.

Meth. Enzymol. 182 , 83-89, (1990)

L-Valinamide, N-[[(1-carboxy-2-phenylethyl)amino]carbonyl]-N-(diaminomethylene)-L-ornithyl-N-[4-[(diaminomethylene)amino]-1-formylbutyl]-, hydrochloride (1:2)

N-[(1-Carboxy-2-phenylethyl)carbamoyl]-L-arginyl-N-(5-carbamimidamido-1-oxopentan-2-yl)-L-valinamide dihydrochloride

MFCD00135957

antipain, dihydrochloride

N-[(1-Carboxy-2-phenylethyl)carbamoyl]-N-(diaminomethylene)-L-ornithyl-N-{5-[(diaminomethylene)amino]-1-oxo-2-pentanyl}-L-valinamide dihydrochloride

L-valinamide, N-[[(1-carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, hydrochloride (1:2)

Antipain

GL Biochem (Shanghai) Ltd.
China
Product Name: Antipain
Price: $Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

DC Chemicals Limited
China
Product Name: BDBM32804
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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BDBM32804

Use of BDBM32804

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BDBM32804 Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

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Synonyms