LY-487379
Modify Date: 2024-01-14 10:11:27
LY-487379 structure
|
Common Name | LY-487379 | ||
|---|---|---|---|---|
| CAS Number | 353231-17-1 | Molecular Weight | 452.44700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19F3N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LY-487379LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research[2]. |
| Name | 2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research[2]. |
|---|---|
| Related Catalog | |
| In Vivo | LY487379 (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage[1]. LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats[1]. |
| References |
| Molecular Formula | C21H19F3N2O4S |
|---|---|
| Molecular Weight | 452.44700 |
| Exact Mass | 452.10200 |
| PSA | 77.11000 |
| LogP | 5.86200 |
| HS Code | 2935009090 |
|---|
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
| 4-mppts |